Prognostic Significance of Eosinophil Extracellular Traps in Chronic Rhinosinusitis and Innovative Nanosheets‐Based Clearance Therapy

作者：Changhui Chen, Hang Li, Yilin Hou, Yihui Wen, Jian Li, Hua Zhong, Tong Lu, Zhengqi Li, Li Sun, Shimin Lai, Yan Yan, Jieying Yan, Zihan Qiu, Nan Zhang, Claus Bachert, Zhaoxu Tu, Weiping Wen, Yi Wei · 发表于：Clinical & Experimental Allergy · 年份：2026 · DOI：10.1111/cea.70235 · 被引用次数：2 · 研究领域：Sinusitis and nasal conditions、Cystic Fibrosis Research Advances、Asthma and respiratory diseases

ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) can be classified into Eosinophilic CRSwNP (ECRSwNP) and non‐Eosinophilic CRSwNP (nECRSwNP) based on eosinophilic infiltration in nasal polyps. However, no consensus criteria exist for eosinophilic infiltration in nasal polyps, including different cutoffs for eosinophil (EOS) counts or different EOS proportions among inflammatory cells. Methods Inferior turbinate (IT) tissues from controls ( n = 27) and nasal polyp (NP) tissues from ECRSwNPs ( n = 50) were collected. ECRSwNPs ( n = 38) underwent 2‐year post‐FESS follow‐up. Clinical assessments (SNOT‐22, Lund‐Mackay, Lund‐Kennedy scores), eosinophil indicators (polyp/blood EOS counts, EETs area), and Th2 cytokines pre/post‐FESS were recorded for correlation analysis and prognostic model building. Subsequently, functional nanosheets TLPG A targeting EETs were synthesized and tested for EETs clearance in human EOS, epithelial cell models, and NP models. Results Our findings demonstrated positive correlations between EETs area and ECRSwNP severity, including Lund‐Mackay CT scores ( r = 0.72, p < 0.001), Lund‐Kennedy Endoscopic score ( r = 0.57, p < 0.001), IL‐4 ( r = 0.50, p < 0.001), IL‐5 ( r = 0.50, p < 0.001), IL‐13 ( r = 0.39, p < 0.01), and Periostin ( r = 0.34, p < 0.05). And we first demonstrated that increased preoperative EETs area predicts both impaired mucosal recovery and elevated nasal polyp uncontrolled risk within 2 years post‐F...