Quantification of per- and polyfluoroalkyl substances in plasma and follicular fluid of patients undergoing in vitro fertilization in Iowa: A pilot study

作者：Prapti Singh-Herren, Samantha Good, Karen M. Summers, Joseph A. Charbonnet, Amy E. Sparks, Aileen F. Keating · 发表于：F&S Reports · 年份：2026 · DOI：10.1016/j.xfre.2025.11.009 · 被引用次数：1 · 研究领域：Per- and polyfluoroalkyl substances research、Effects and risks of endocrine disrupting chemicals、Pharmacological Effects and Assays

Per- and polyfluoroalkyl substances (PFAS) are a class of persistent synthetic chemicals that impart oil, water, and stain repellency to products. The use of PFAS has expanded in industrial and consumer products, including cleaning, personal care, and food items. The PFAS are absorbed via the gastrointestinal tract, respiratory system, and skin, after which they accumulate in the liver through interactions with fatty acid-binding proteins. They subsequently are distributed systemically via noncovalent binding to serum albumin, facilitating their presence in tissues, such as plasma and follicular fluid.