Trends and cross-country disparity in the burden of pulmonary arterial hypertension among women of childbearing age from 1990 to 2021

作者：Liyuan Chen, Xiaojie Wu, Xuemei Gao · 发表于：Frontiers in Global Women s Health · 年份：2026 · DOI：10.3389/fgwh.2025.1651601 · 研究领域：Pulmonary Hypertension Research and Treatments、Pregnancy and preeclampsia studies、Cardiovascular Issues in Pregnancy

Introduction: There is currently a lack of comprehensive literature analysis on the global burden and trends of pulmonary arterial hypertension (PAH) among women of childbearing age (WCBA). We fill this evidence gap by evaluating the burden and temporal trends of PAH in WCBA at global, regional, and national levels from 1990 to 2021. Methods: Data about PAH burden were extracted from the Global Burden of Disease Study (GBD) 2021. Moreover, PAH burden was explored across regions with different age, social development index (SDI) or health system. Results: There was a significant global increase in incident and prevalent cases of PAH among WCBA. Disability-adjusted life years (DALYs) and deaths initially increased but began to decline after 2010. Age-standardized incident rate (ASIR) and age-standardized prevalent rate (ASPR) increased in all SDI regions except in low SDI. Low and low-middle SDI regions bore the heaviest burden. Basic and limited healthcare systems showing the most pronounced increases in cases, but with advanced healthcare systems demonstrating a sharp reduction in age-standardized rates (ASR) of DALYs and deaths. Geographically, the highest ASIR were observed in Sub-Saharan Africa regions. Meanwhile, Central Asia and Tropical Latin America had the highest ASR of DALYs and deaths. National-level analysis identified India and China with the highest case numbers, and Sweden with the highest ASPR. Mauritius, Mongolia and Tajikistan topped ASR of DALYs and deaths....