Exploration and clinical analysis of the correlation between the triglyceride–glucose index and hyperuricemia in patients with type 2 diabetes: a real-world, retrospective, cross-sectional study with subsequent cohort analysis

作者：Dachuan Xia, Chang Li, Xiaoqiang Sun, Xiao Huang, Zheng Wang, Zhaohu Hao, Hailin Shao · 发表于：BMC Endocrine Disorders · 年份：2026 · DOI：10.1186/s12902-026-02188-z · 被引用次数：2 · 研究领域：Gout, Hyperuricemia, Uric Acid、Diabetes, Cardiovascular Risks, and Lipoproteins、Diet, Metabolism, and Disease

OBJECTIVE: We herein explored the correlation between the triglyceride-glucose index (TyGI) and hyperuricemia (HUA) in patients with type 2 diabetes (T2DM). METHODS: Patients with T2DM who visited the Metabolic Disease Management Center (MMC) of Tianjin Fourth Central Hospital from October 2017 to August 2024 were selected as our study subjects. We measured fasting plasma glucose (FPG), triglyceride (TG), serum uric acid (SUA), and glycated hemoglobin levels (HbA1c); calculated the TyGI; and initially conducted a cross-sectional study to analyze the association between TyGI and HUA. A two-year retrospective cohort study was subsequently performed to further investigate the correlation between TyGI and the risk of developing HUA, and its resolution. RESULTS: A total of 11,806 patients were included, with 6,759 completing SUA tests. Of these patients, 1,270 patients (18.8%) manifested concurrent HUA; and 46.6% were newly diagnosed cases. Spearman correlation analysis revealed a significant positive correlation between TyGI and SUA levels in 4,520 T2DM patients who had not taken uric acid-lowering drugs in the previous month (r = 0.23, p < 0.001). Logistic regression analysis indicated that maleness, obesity, smoking, and high TyGI (OR = 1.95, p < 0.001) were significantly associated with HUA. In a two-year retrospective cohort follow-up of 1,074 patients without HUA, 154 patients (14.3%) developed HUA; and COX regression analysis identified male sex, obesity, and a high TyGI du...