Gender-specific impact of follow-up intervals on disease control in rheumatoid arthritis: a nationwide analysis of 15 835 Chinese patients

作者：Haojie Xu, Liyun Zhang, yuehong huo, Rui Wu, Lijun Wu, Ling Lei, L G Geng, Chunyu Tan, Xiaomei LI, Ru Li, Yin Su, Liyun Zhang, yuehong huo, Rui Wu, Lijun Wu, Ling Lei, L G Geng, Yin Su, Chunyu Tan, Xiaomei LI, Zhanyun Da, Xiaofei Shi, Caihong Wang, Hongyan Wen, Wenjie Zheng, Xiaomei Leng, Wen Zhang, Fuai Lu, Yufeng Qing, Lin Pan, Mingshu Sun, Li Sun, Peirong Chen, Yongji Li, Xiaoru Xia, Jing Yang, Wei Wei, Yisha Li, Chunhua Shi, Jin Lin, Jin Zhang, Xiaodong Wang, Qiang Shu, Mu Rq, Linjie Chen, Kexia Chai, Haiying Chen, Ping Li, Juan Du, Huifang Guo, Jing Lu, Pingting Yang, Ling Zhao, Ling Zheng, Lie Dai, Hua Wei, Ying Liu, Jing Wang, Fen Li, Jing Zhu, Xuemei Tian, Jie Gao, Wenjia Sun, Lei Liu, Qiaohong Wang, Yun Zhao, Juan Li, Weinan Lai, Fei Gao, Shuyan Yang, Huaxiang Wu, Wei Liu, Ou Jin, Wufang Qi, Zhaohui Zheng, Yang Liu, Ning Tie, Shuhong Chi, Juan Chen, Yanying Liu, Xin Lu, Haili Shen, Miaojia Zhang, Qin Li, Supin Li, Xiaoqi Chen, Wei Zhang, Qingwen Wang, Fengju Li, Jing Yu, Yan Zhang, Xiaodan Kong, Wei Ji, Jinyu Wu, Yanping Zhao, Tao Yue, Qing Zhao, Qian Wu, Xiaoyan Li, Jin Ding, Yuan Li, Tianli Ren, Yaping Luo, Yuhua Wang, Yi Yang, Jihua Wang, Fuhai Feng, Hongtao Guo, Zihua Wang, Yuan Liu, Danan Yang, Shuyun Wen, Ling Li, Yanxin Li, Yunjing Bai, Fan Wu, Fengxia Wang, Xiaohong Lv, Jinying Lin, Fengyan Sun, Lifeng Ping, Xinfang Huang, Hui Liu, Lingli Dong, Xiujie Song, Xinying Liu, Lin Liu, Hui Song, Jinhua Yan, Shushan Zhao, Zhongming Yu, Xin Wang, Hongwei Qiang, Tao Cheng, Xianming Long, Chunxian Li, Liming Xu, Huifen Yang, Haisheng Zhang, S Y Wang, Qinghua Chang, Lijun Zhang, Yujin Ye, Yongjing Cheng, Yifang Mei, Jingping Hu, Shuai Wang, Gailian Zhang, Lihui Ma, Meipu Chen, Tong Pan, Yasong Li, Minghua Xu, Xiaomin Liu, Dandan Li, Jiasheng Ma, Mei Tian, Linna Pang, Conghui Sun, Li Qin, Xia Yang, Yuxia Ma, Yi Zhang, Ling Lin, Yiling Qian, Xiaoru Li, Ying Liu, Ning Chen, Jiangyun Peng, Linchen Liu, Xiaoyan Xu, Gang Wang, Jia Wang, Lihua Zhang, Jianying Chen, Rong Du, Yuan Gao, Li Cui, Guoqing Li, Wei Zhou, Lei Luo, Dandan Chen, Guofeng Wang, Dengxiao Zhang, Xinyao Zhou, Quan Jiang, Shujuan Zhou, Dinglei Su, Xingguo Chen, Shaojun Zhang, Lianjie Shi, Chunyan Zhang, Zhengfang Zhang, Jian Wang, Xuan Xia, Qianwen Yang, Fan Wang, Wei Gou, Shifang Chen, Yu Mei, Jing Liu, Hongyan Xu, Feng Yue, Wei Hu, Meimei Xu, Dongmei Xiao, Zhen Zhang, Sheng Chen, L. Pan, Baoyu Zhang, Lihuan Guo, Dongmei Zhou, Hua Ma, Tianrong Guan, Qunfeng Dai, Shuang Fu, Ge Zhang, Xiaojing Zhang, Liangchun Tang, Yaqin Zhu, Shunfang Shi, Na Wu, Yan Li, Junhua Guo, Jianyu Dai, Zhe Liu, Yuan Feng, Tingting Lv, LI Rao, Yuxiu Zhou, Baimayangjin, Ping Fu, Bei Wang, Li Wen, Bin Jia, Menglin Zhao, Binbin Wan, Huiqin Yang, Cuimin Guo, Jian Wu, Yang Li, Xuehong Lu, Yong Chen, Linxiao Ma, Yuling Wang, Xiaohong Ji, Qiong Jiang, Lingfei Guo, Kuanting Wang, Xuqiang Jia, Yinong Li, Shengfei Li, Lixia Pang, Li Li, Jianmin Xie, Fang Lv, Xiaobei An, Dongyu Chen, Minfang Yuan, Yunxia Liu, Pingle Wang, Lijie Yu, Jiping Wu, Haiyan Yu, Yadong Zhou, Ying Huang, Bin Wang, Jiaxuan Li, Feng Zhu, Li Wu, Haiyan Tong, Huixia Xiong, Yu Liu, Tieyan Hong, Danqing Huang, Yujuan Shen, Jie Bai, Wenhong Cai, Juan Guo, Bao Li, Silu Wei, Wei Wei, Xinhua Zhang, Huiling Qian, Lijuan Zhu, Fang Ma, Ji Luo, Pan Zhou, Chunyan Chen, Luyao Wang, Zhengang Wang, Li Liang, Ruirui Wang, Lihua Li, Min Wu, Guoliang Yao, Hongli Sun, ShouJun Wang, X Liu, Jiao Huang, 郑红霞, Yayu Li, Qiuling Ding, Fang Li, Qingliang Meng, Jiahui Zhao, Lijuan Gao, Huiling Li, Xingfa Tao, Yan Liu, Xianghua Guo, Huifang Li, Zhenying Li, Ji Qi, Ning Yang, Baijie Xu, Jia Fan, Shuang Liu, Jiajia Wang, Zhen Zhang, Nie Jin, Xiaodong Wang, Tong Liu, Yingying Gao, Zhichao Wang, Xiuqin Ma, Xuemei Yu, Jinhui Fu, Xuling Yang, Shuang Gao, Yufang Lou, Yang Zhang, Limei Gu, Zhanfeng Gong, Yingliang Wang, Bin Qiao, Y Chen, Qun Zheng, Luyang Zhang, Xiaoling Li, Yanchun Tang, Wei Zhang, Na Wang, Y. Wang, Yi Dai, Xiaodong Zhu, Shuping Zhong, Wenqian Song, Yanping Qi, Guomin Sun, Xiaolian Liu, Wancang Yao, Bo Lou, Fengjin Xu, Q. K. Wu, Yan Shen, Jie Shen, Lin Zheng, Hongjian Yuan, Yanfei Chen, Yanqiu Wei, Lei Yang, Shengdong Li, Shan Huang, Wenze Xiao, Yeying Yang, Yikun He, Jingjun Wang, Kejia Yu, Hui Zhao, Ying Guan, Li Wang, Lina Wang, Xiaolu Huang, Zhuo Deng, Jianhui Ma, Yanni Wang, Yanling Wang, Yafei Pang, Ying Liu, Jingye Liao, Hui Shi, Yingxue Wang, Yuewu Lu, Xiaoling Liu, Liangliang Gong, Yu Xue, Xiaoyan Cai, Jing Zhang, Li Zhao, Jiangli Xia, Yun Guo, Huiyuan Li, Lindi Jiang, Jingyang Li, Xia Dong, Chunying Liu, Zhichun Liu, Yingkun Nie, Yan Wang, Ming Gui, Pei Wang, Jun Sheng, Wenqian Li · 发表于：Lara D. Veeken · 年份：2026 · DOI：10.1093/rheumatology/keag079 · 研究领域：Rheumatoid Arthritis Research and Therapies、Systemic Lupus Erythematosus Research、Diabetes Management and Education

OBJECTIVES: Previous studies have identified unique challenges for RA patients of different genders, which impact disease management. However, the association between disease activity and health-care-seeking behaviours in male and female RA patients remains underexplored. This study aimed to investigate this association, with a specific focus on the gender-specific effects of follow-up intervals on disease control. METHODS: A nationwide survey (July-September 2023) across 330 rheumatology centres in China included 13 278 female (83.85%) and 2557 male RA patients (16.15%) aged ≥18 years. Standardized questionnaires captured demographic and health-care-seeking behaviours. Disease activity was assessed using the Clinical Disease Activity Index (CDAI). RESULTS: Females had younger disease onset (45.84 vs 51.03 years, P < 0.001), longer disease duration (7.51 vs 5.64 years, P < 0.001), higher low disease activity/clinical remission rates (22.61% vs 15.33%, P < 0.001), and lower glucocorticoid use (39.5% vs 47.73%, P < 0.001). Despite similar self-reported regular follow-up rates (84.73% vs 83.14%), both genders experienced suboptimal visit intervals (>3 months: 61.30% vs 62.65%, P < 0.001). Prolonged follow-up intervals were independently associated with poor disease control (CDAI > 10) in the female subgroup, with longer intervals linked to higher odds of inadequate control at 6-month [odds ratio (OR) = 1.22, 95% CI: 1.09-1.37, P < 0.001] and 12-month intervals (OR = 1.43, 95% CI...