Total Synthesis of (±)- and (+)-Euphohyrisnoid A

作者：Zhanhong Ye, Qiao-Qiao Ao, Yang-Chao Peng, Xin Liu, X. Sheldon Lin, Chuang‐Chuang Li · 发表于：Journal of the American Chemical Society · 年份：2026 · DOI：10.1021/jacs.6c00187 · 被引用次数：4 · 研究领域：Bioactive Natural Diterpenoids Research、Biological Activity of Diterpenoids and Biflavonoids、Plant-based Medicinal Research

diterpenoid with a new [5-7-6-6] tetracyclic core, was accomplished. The synthesis was strategically guided by a mild intramolecular Diels-Alder (IMDA) reaction, which efficiently constructed the pivotal bicyclo[2.2.2] ring system with high diastereoselectivity. This outcome experimentally validated prior quantum mechanical calculations. The IMDA precursor was assembled efficiently via a Tsuji-Trost reaction. The desired seven stereocenters, including two quaternary stereocenters in the final product, were constructed diastereoselectively.