Predictive models for acute kidney injury in acute pancreatitis: a systematic review and meta-analysis

作者：Haoran Zhu, Feifei Li, Shengteng Guo, Yijun Xiao, Wentao Zhu, Qinghua Wang · 发表于：Frontiers in Medicine · 年份：2026 · DOI：10.3389/fmed.2025.1699717 · 被引用次数：1 · 研究领域：Pancreatitis Pathology and Treatment、Acute Kidney Injury Research、Muscle and Compartmental Disorders

Background: The utilization of predictive models facilitates the identification of patients at risk, thereby enabling the implementation of individualized interventions. Despite the growing use of predictive models to estimate the likelihood of AKI in AP, concerns persist regarding their effectiveness in clinical settings and the rigor and relevance of forthcoming research. The objective of this study is to systematically review and evaluate predictive models for AKI in AP. Methods: A comprehensive search of relevant databases was conducted, encompassing China National Knowledge Infrastructure (CNKI), Wanfang, VIP, Chinese Medical Association, PubMed, Web of Science, Scopus, and Cochrane Library, with the search extending from database inception to 26 November 2024. The data from a number of selected studies was extracted using the CHARMS form, while the quality of predictive modeling studies was assessed using the PROBAST tool. A meta-analysis of AUC for predictive models and relevant predictors (≥2) was conducted using Stata 17.0 and MedCalc software. Results: The total number of studies included in the review was 17, with a total of 9,949 patients and 37 predictive models. Of these, 32 models underwent internal validation, with an area under the curve (AUC) > 0.7. The overall risk of bias was high across all 17 studies, yet the overall applicability was deemed satisfactory. The results of the meta-analysis indicated that the pooled AUC for internal validation across 20 pre...