Psychological and Psychosocial Interventions for People With Schizophrenia and Co-Occurring Substance Use Disorders

作者：Nurul Husna Salahuddin, Emilia Herlitzius, Alexandra Schütz, Spyridon Siafis, Josef Priller, Stefan Leucht, Irene Bighelli · 发表于：JAMA Psychiatry · 年份：2026 · DOI：10.1001/jamapsychiatry.2025.4390 · 被引用次数：3 · 研究领域：Substance Abuse Treatment and Outcomes、Schizophrenia research and treatment、Opioid Use Disorder Treatment

Importance: Substance use disorder (SUD) is commonly found in individuals with schizophrenia, with a high co-occurrence rate of approximately 41.7%. Despite this high prevalence, people with both schizophrenia and SUD are frequently excluded from clinical trials and systematic reviews; this special group is particularly challenging to treat and imposes a significant economic burden on health care systems. Objective: To evaluate the efficacy, acceptability, and tolerability of psychological and psychosocial interventions in patients with schizophrenia and co-occurring SUD. Data Sources: The Cochrane Schizophrenia Group registry was searched up to January 13, 2025. Data analysis was performed from March to April 2025. Study Selection: Randomized clinical trials (RCTs) examining psychological and psychosocial interventions compared with control groups in adults with schizophrenia and concomitant SUD were identified. No restrictions were applied regarding the type of substance used, including alcohol, cannabis, nicotine, and stimulants, such as amphetamines. Data Extraction and Synthesis: A systematic review and random-effect pairwise meta-analyses were conducted to estimate standardized mean differences (SMD) with 95% confidence intervals and were reported following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Confidence in the estimate was assessed with the Grading of Recommendations Assessment, Development and Evaluation (GR...