Prevalence and spatial distribution characteristics of human brucellosis in Ningxia from 2010 to 2024

作者：Hongju Duan, Xianglin Wu, Zhenhua Lei, Yu Zhao, Tianbo Ma, Tinglong Yang, Zhiyi Wang, Mingzhe Jiang, Liying Wang, Xueping Ma · 发表于：PLoS neglected tropical diseases · 年份：2026 · DOI：10.1371/journal.pntd.0013910 · 被引用次数：2 · 研究领域：Brucella: diagnosis, epidemiology, treatment、Zoonotic diseases and public health、Parasitic Diseases Research and Treatment

BACKGROUND: Brucellosis, a neglected zoonotic disease as defined by the World Health Organization (WHO), represents a substantial burden, causing both severe human morbidity and significant economic losses to the livestock industry. In recent years, the Ningxia Hui Autonomous Region (Ningxia) in northwest China has emerged as a region with persistently high endemicity of human brucellosis. An in-depth analysis of the epidemic's prevalence and spatiotemporal evolution in this region is essential to inform the optimization of targeted prevention and control measures. METHODS: Data on all human brucellosis cases from 2010 to 2024 were collected from the China Information System for Disease Control and Prevention. Temporal trends, global and local spatial autocorrelation, and spatial scan statistics were used to explore temporal patterns, regional clustering, and high-risk areas. RESULTS: A total of 35 665 human brucellosis cases were reported in Ningxia, with no associated deaths, during the study period. The average annual incidence rates was 35.08/100,000, ranging from 3.31 to 84.80 per 100,000. Two incidence peaks were observed: the first in 2015 (43.66/100,000) and the second in 2022 (84.80/100,000). The human brucellosis incidence rates showed that overall increasing trend from 2010 to 2024 (average annual percentage change [AAPC]=18.31%, but this was not statistically significant (t = 1.63, P = 0.102). Male accounted for 71.01% (25 325 cases) of all cases, 2.45 times highe...