Deep learning enhanced ALPS reveals genetic and environmental factors of brain glymphatic function

作者：Cha Lin, Hao Wu, Wenbiao Xian, Yifan Zheng, Wenxuan Du, Xinyi Chen, Jinxia Li, Weineng Chen, Lishan Lin, Fengjuan Su, Zhong Pei, Ganqiang Liu, Michael W. Weiner, Paul S. S Aisen, Ronald Petersen, Michael W. Weiner, Paul S. S Aisen, Ronald Petersen, Clifford R Jack, Jagust Wj, Susan M. Landau, Monica Rivera-Mindt, Ozioma Okonkwo, Leslie Shaw, Edward B. Lee, Arthur W Toga, Laurel A. Beckett, Danielle J. Harvey, Robert C. Green, Andrew J. Saykin, Kwangsik Nho, Richard J. Perrin, Duygu Tosun, Pallavi Sachdev, Robert C. Green, Tom Montine, Cat Conti, Michael W. Weiner, Rachel Nosheny, Juliet Fockler, Melanie J. Miller, Winnie Kwang, Chengshi Jin, Adam Diaz, M. Ashford, Ronald Petersen, Paul S. S Aisen, Michael S. Rafii, REMA RAMAN, Gustavo Jimenez, Michael Donohue, Jennifer Salazar, Andrea Fidell, Virginia Boatwright, Justin Robison, Caileigh Zimmerman, Yuliana Cabrera, Sarah Walter, Taylor Clanton, Elizabeth Shaffer, Caitlin Webb, Lindsey Hergesheimer, Stephanie Smith, Sheila Ogwang, Olusegun Adegoke, Payam Mahboubi, Jeremy Pizzola, Cecily W. Jenkins, Laurel A. Beckett, Danielle J. Harvey, Michael Donohue, Naomi Saito, Adam Diaz, Kedir Adem Hussen, Ozioma Okonkwo, Monica Rivera-Mindt, Shaniya Parkins, Omobolanle Ayo, Kaori Kubo Germano, Joe Strong, Vanessa Guzman, Adeyinka O Ajayi, Joseph Di Benedetto, Sandra Talavera, Clifford R Jack, Felmlee JP, Nick C Fox, Paul M. Thompson, Charles S DeCarli, Arvin Arani, Bret Borowski, Calvin D. Reyes, Caitie Hedberg, Chad Ward, Christopher Schwarz, Denise Lucia Reyes, Jeff Gunter, John Moore-Weiss, Kejal Kantarci, Leonard C. Matoush, Matthew L. Senjem, Prashanthi Vemuri, Robert Reid, Ian B. Malone, Sophia I. Thomopoulos, Talia M. Nir, Neda Jahanshad, Alexander Knaack, Evan M. Fletcher, Danielle J. Harvey, Duygu Tosun, Stephanie Rossi Chen, Mark Choe, Paul A. Yushkevich, Sandhitsu Das, Jagust Wj, Susan M. Landau, Robert A. Koeppe, Gil Rabinovici, Victor Villemagne, Brian J. Lopresti, Richard J. Perrin, John Morris, Erin Franklin, Haley Bernhardt, Nigel J. Cairns, Lisa Taylor‐Reinwald, Leslie Shaw, Edward B. Lee, Magdalena Korecka, Magdalena Brylska, Yang Wan, Arthur W Toga, Karen Crawford, Scott Neu, Andrew J. Saykin, Kwangsik Nho, Tatiana M. Foroud, Taeho Jo, Shannon L. Risacher, Hannah Craft, Liana G Apostolova, Kelly Nicole Holohan Nudelman, Kelley M. Faber, Kaci Lacy, Rima Kaddurah-Daouk, Li Shen, David Soleimani-Meigooni, Renaud La Joie, Konstantinos Chiotis, Maison Abu Raya, Agathe Vrillon, Charles Windon, Julien Lagarde, Zoe Lin, Aidyn Rose Hills, Jason H. Karlawish, Claire Erickson, Joshua D. Grill, Michael W. Weiner, Leon Thal, Zaven Kachaturian, Richard Frank, Peter J. Snyder, Neil Buckholtz, John K Hsiao, Laurie Ryan, Susan Molchan, Zaven S. Khachaturian, María Cristina Carrillo, William Potter, Lisa Barnes, Marie, Hector Bernard, González, Carole Ho, John K Hsiao, Jonathan Jackson, Eliezer Masliah, Donna M. Masterman, Ozioma Okonkwo, Richard J. Perrin, Laurie Ryan, Nina Silverberg, Lisa C Silbert, Jeffrey A. Kaye, Sylvia White (Salazar), Aimee L. Pierce, Amy Thomas, Tera Clay, Daniel Schwartz, Gillian Devereux, Jennifer L. Ryan, Mike Nguyen, Madison DeCapo, Yanan Shang, Lon Schneider, Cynthia Munoz, Diana Ferman, Carlota Conant, Katherin Martin, Kristin Oleary, Sonia Pawluczyk, Elizabeth Trejo, Karen Dagerman, Liberty Teodoro, Mauricio Becerra, Madiha Fairooz, Sonia Garrison, Julia Boudreau, Yair Avila, James M. Brewer, Aaron Jacobson, Antonio Gama, Chi Kyung Kim, Emily Little, Jennifer Frascino, Nichol Ferng, Socorro Trujillo, Judith L. Heidebrink, Robert A. Koeppe, Steven MacDonald, Dariya Malyarenko, Jaimie Ziolkowski, James O'Connor, Nicole Robert, Suzan Lowe, Virginia Rogers, Ronald Petersen, Barbara Hackenmiller, Bradley Boeve, Colleen Albers, Connie Kreuger, David Jones, David Knopman, Hugo Botha, Jessica Magnuson, Jonathan Graff‐Radford, Kerry Crawley, Michaël Schumacher, Sanna McKinzie, Steven Smith, Tascha Helland, VJ Lowe, Vijay Ramanan, Valory Pavlik, Jacob Faircloth, Jeffrey Bishop, Jessica Nath, Maria Chaudhary, Maria Kataki, Melissa B. Yu, Nathiel Pacini, Randall Barker, Regan Brooks, Ruchi Aggarwal, Lawrence Honig, Yaakov Stern, Akiva Mintz, Jonathan Cordona, Michelle Hernandez, Justin M. Long, Abbey Arnold, Alex Groves, Anna Middleton, Blake Vogler, Cierra McCurry, Connie Mayo, Cyrus A. Raji, Fatima S. Amtashar, Heather Klemp, Heather Nicole Elmore, James Ruszkiewicz, Jasmina Kusuran, Jasmine Stewart, Jennifer Horenkamp, Julia Greeson, Kara Wever, Katie Vo, Kelly Larkin, Lesley K. Rao, Lisa Schoolcraft, Lora Gallagher, Madeline Paczynski, Maureen McMillan, Michael Holt, Nicole Gagliano, Rachel L. Henson, Renee LaBarge, Robert Swarm, Sarah Munie, Serena Cepeda, Stacey Winterton, Stephen Hegedus, TaNisha Wilson, Tanya Harte, Zach Bonacorsi, David Geldmacher, Amber Watkins, Brandi Barger, Bryan Smelser, Charna Bates, Cynthia Stover, Emily McKinley, Gregory Ikner, Haley Hendrix, Harold Matthew Cooper, J. A. Mahaffey, Lindsey Booth Robbins, Loren Brown Ashley, Marissa Natelson-Love, Princess Carter, Veronika Solomon, Hillel Grossman, Alexandra M. Groome, Allison Ardolino, Anthony Kaplan, Faye Sheppard, Genesis Burgos-Rivera, Gina Garcia-Camilo, Joanne Lim, Judith Neugroschl, Kimberly Jackson, Kirsten Evans, Laili Soleimani, Mary Sano, Nasrin V. Ghesani, Sarah Binder, Xiomara Mendoza Apuango, Ajay Sood, Amelia Troutman, Kimberly S. Blanchard, Arlene Richards, Grace Nelson, Kirsten Hendrickson, Erin Yurko, J. Plenge, Victoria Rufo, Raj D Shah, Ranjan Duara, Brendan Lynch, Cesar L. Chirinos, Christine Dittrich, Debbie Campbell, Diego Mejia, Gilberto Perez, Helena Colvee, Joanna Gonzalez, Josalen Gondrez, Joshua Knaack, Mara Acevedo, Maria Cereijo, Maria Greig-Custo, Michelle Villar, Morris Wishnia, Sheryl Detling, Warren Barker, Marilyn Albert, Abhay Moghekar, Barbara Rodzon, Corey Demsky, Gregory M. Pontone, Jim J. Pekar, Leonie Farrington, Martin G. Pomper, Nicole Johnson, Tolulope Alo, Martin C. Sadowski, Anaztasia Ulysse, Arjun V. Masurkar, Brittany Marti, David J. Mossa, Emilie Geesey, Emily Petrocca, Evan Schulze, Jennifer Wong, Joseph Boonsiri, Sunnie Kenowsky, Tatianne Martinez, Veronica Briglall, Pudugramam Murali Doraiswamy, Adaora Ngozi Nwosu, Alisa Adhikari, Cammie Hellegers, Jeffrey Petrella, Olga G James, Terence C. Wong, Thomas C. Hawk, Sanjeev Vaishnavi, Hannah McCoubrey, Ilya Nasrallah, Rachel Rovere, Jeffrey Maneval, Elizabeth Robinson, Francisco Rivera, Jade Uffelman, Martha Combs, Patricia C. O'Donnell, Sara Manning, Richard King, Alayne Nieto, Amanda C. Glueck, Anjana Mandal, Audrie Swain, Bethanie Gamble, Beverly Meacham, Denece Forenback, Dorothy Ross, Elizabeth Cheatham, Ellen Hartman, Gary R. Cornell, J Harp, Laura Ashe, Laura Goins, Linda Watts, Morgan Yazell, Prabin Mandal, Regan Buckler, Sylvia Vincent, Triana Rudd, Oscar Lopez, Ann Arlene Malia, Caitlin Chiado, Cary Zik, James Ruszkiewicz, Kathleen Savage, Linda Fenice, MaryAnn Oakley, Paige C Tacey, Sarah Berman, Sarah Bowser, Stephen Hegedus, Xanthia Saganis, Anton Porsteinsson, Abigail Mathewson, Asa Widman, Bridget Holvey, Emily Clark, Esmeralda Morales, Iris Young, James Ruszkiewicz, Kevin Hopkins, Kimberly Martin, Nancy Kowalski, Rebecca Hunt, Roberta Calzavara, Russell Kurvach, Stephen D’Ambrosio, Gaby T. Thai, Beatriz Vides, Brigit Lieb, Catherine McAdams-Ortiz, Cyndy Toso, Ivan Mares, Kathryn Moorlach, Luter Liu, Maria Corona, Mary Nguyen, Melanie Tallakson, Michelle McDonnell, Milagros Rangel, Neetha Basheer, Patricia Place, Romina Romero, Steven Tam, Trung Kien Nguyen, Abey Kozhimannil Thomas, Alka Khera, Amy Browning, Brendan Kelley (031), Courtney K. Dawson, Dana Mathews, Elaine Most, Lynn Nguyen, Maribel Nunez, Matalin Miller, Matthew R. Jones, Natalie N. Martinez, Rebecca Logan, Roderick W. McColl, Sari Pham, Tiffani Fox, Tracey Moore, Allan I. Levey, Abby Brown, Andrea J. Kippels, Ashton C. Ellison, Casie Lyons, Chadwick Hales, Cindy Parry, Courtney Williams, Elizabeth McCorkle, Guy Harris, Heather Rose, Inara Jooma, Jahmila Al-Amin, James Lah, James R. Webster, Jessica Swiniarski, Latasha Chapman, Laura Donnelly, Lauren Mariotti, Mary C. Locke, Phyllis P. Vaughn, Rachael Penn, Sallie Carpentier, Samira Yeboah, Sarah Basadre, Sarah Malakauskas, Stefka Lyron, Tara Villinger, Terra Burney, Jeffrey Murray Burns, Ala Abusalim, Alexandra Dahlgren, Alexandria Montero, Anne Arthur, Heather Dooly, Katelynn Kreszyn, Katherine Berner, Lindsey Gillen, Maria Scanlan, Mercedes Madison, Nicole Mathis, Phyllis Switzer, Ryan Townley, Samantha Fikru, Samantha Sullivan, Ella Wright, Maryam Beigi, Anthony Daley, Ashley Ko, Brittney Luong, Glen K. Nyborg, Jessica Y. Morales, Kelly M. Durbin, Lauren Garcia, Leila Parand, Lorena Macias, Lorena H. Monserratt, Maya Farchi, Pauline Wu, Robert Nick Hernandez, Thao Rodriguez, Neill Graff-Radford, A’llana Marolt, Anton Thomas, Deborah Aloszka, Ercilia Moncayo, Erin M. Westerhold, Gregory Day, Kandise Chrestensen, Mary Imhansiemhonehi, Sanna McKinzie, Sochenda Stephens, Sylvia Grant, Jared Brosch, Amy M. Perkins, Aubree Saunders, Debra Silberberg Kovac, Heather Polson, Isabell Mwaura, Kassandra Mejia, Katherine Britt, Kathy King, Kayla D. Nichols, Kayley Lawrence, Lisa K. Rankin, Martin Farlow, Patricia Wiesenauer, Robert G. Bryant, Scott Herring, Sheryl Lynch, Skylar Wilson, Traci Day, William Korst, Christopher van Dyck, Adam P. Mecca, Alyssa Miller, Amanda Brennan, Amber Khan, Audrey Ruan, Carol Gunnoud, Chelsea Mendonca, Danielle Raynes-Goldfinger, Elaheh Salardini, Elisa Hidalgo, Emma Cooper, Erawadi Singh, Erin Murphy, Jeanine May, Jesse Stanhope, Jessica Lam, Julia Waszak, Kimberly Nelsen, Kimberly Sacaza, Mayer Joshua Hasbani, Meghan Donahue, Ming-Kai Chen, Nicole M. Barcelos, Paul Eigenberger, Bonomi Robin, Ryan S. O’Dell, Sarah Jefferson, Siddharth Khasnavis, Stephen Smilowitz, Susan DeStefano, Susan Good, Terry Camarro, Vanessa Clayton, Yanis Cavrel, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Anish N. 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Johnson, Kathryn Turner, Katie Seidenberg, Kelly McCann, Margaret Bassett, Melanie Chadwick, Raymond Scott Turner, Robin Bean, Saurabh Sharma, Gad Marshall, Aferdita Haviari, Alison Pietras, Bradley J. Wallace, Catherine Munro, Gladiliz Rivera‐Delpin, Hadley Hustead, Isabella M. Levesque, Jennifer Ramirez, Karen Nolan, Kirsten Glennon, Mariana Palou, Michael Erkkinen, Nicole DaSilva, Pamela Friedman, Regina Silver, Ricardo Salazar, Roxxanne Polleys, Scott McGinnis, Seth Gale, Tia C. Hall, Tuan Luu, Steven Z. Chao, Emmeline Y. Lin, Jaila Coleman, Kevin S. Epperson, Minal Vasanawala, Alireza Atri, Amy Rangel, Brittani Evans, Candy Monarrez, Carol Cline, Carolyn Liebsack, Daniel J. Bandy, Danielle Goldfarb, Debbie Intorcia, Jennifer Olgin, Kelly Clark, Kelsey T. King, Kylee A. York, Marina Reade, Michael Callan, Michael Glass, Michaela Johnson, Michele Gutierrez, Molly Goddard, Nadira Trncic, Parichita Choudhury, P. V. Reyes, Serena Lowery, Shaundra Hall, Sonia Olgin, Stephanie Santiago, Michael Louis Alosco, Alyssa Ton, Amanda Jiménez, Andrew Ellison, Anh Tran, Brandon Anderson, Della Carter, Donna Veronelli, Steven Lenio, Eric Steinberg, Jesse Mez, Jason Weller, Jennifer Johns, Jesse Mez, Jessica Harkins, Alexa Puleio, Ina Hoti, Jane Mwicigi, Alexa Puleio, Michael Louis Alosco, Olivia Schultz, Mona Lauture, Eric Steinberg, Ridiane Denis, Ronald Killiany, Sarab Singh, Steven Lenio, Wendy Qiu, Ycar Devis, Thomas Olabode Obisesan, Andrew Stone, Debra Ordor, Ifreke Udodong, Immaculata Okonkwo, Javed Khan, Jillian Turner, Kyliah Hughes, Oshoze Kadiri, Charles J. Duffy, Ariana Moss, Katherine Stapleton, Maria Toth (fmr Gross), Marianne Sanders, Martin Ayres, Melissa Hamski, Parianne Fatica, Paula K. Ogrocki, Sarah Ash, Stacy Pot, Doris Chen, Andres Soto, Costin Tanase, David Bissig, Hafsanoor Vanya, Heather Russell, Hitesh Patel, Hongzheng Zhang, Kelly Wallace, Kristi Ayers, Maria Gallegos, Martha Forloines, Meghan Sinn, Queennie Majorie S Kahulugan, Richard Isip, Sandra Calderon, Talia Hamm, Michael Borrie, T.Y. Lee, Dr Rob Bartha, Sterling Johnson, Asthana Sanjay, Cynthia M. Carlsson, Allison Perrin, Pierre Tariot, Adam Fleisher, Stephanie Reeder, Horacio A. Capote, Allison Emborsky, Anna G. Mattle, Béla M. Ajtai, Benjamin Wagner, Bennett A. Myers, Daryn Slazyk, Delaney Fragale, Erin Fransen, Heather Macnamara, J M Falletta, Joseph Hirtreiter, Laszlo L. Mechtler, Megan King, Michael Asbach, Michelle Rainka, Richard Zawislak, Scott Wisniewski, Stephanie O'Malley, Tatiana Jimenez-Knight, Todd Peehler, Traci S. Aladeen, Vernice Bates, Violet Wenner, Wisam Elmalik, D W Scharre, Arun Ramamurthy, Soumya Bouchachi, Maria Kataki, Rawan M. Tarawneh, Brendan Kelley (031), Dzintra F. 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Miller, Amanda Smith, Ijeoma Mba, Jenny Echevarria, Juris Janavs, Emily Roglaski, Meagan Yong, Rebecca Devine, Hamid Reza Okhravi, Edgardo Rivera, Teresa Kalowsky, Caroline Smith, Christina Rosario, Joseph Masdeu, Richard Le, Maushami Gurung, Marwan Noel Sabbagh, Angelica Garcia, Micah Ellis Slaughter, Nadeen Elayan, Skieff Acothley, Nunzio Pomara, Raymundo Hernando, Vita Pomara, Chelsea Reichert, Olga Brawman-Mintzer, Allison Acree, Arthur G. Williams, Campbell Long, Rebecca F.P. Long, P A Newhouse, Sydni Jenee Hill, Amy Boegel, Sudha Seshadri, Amy Saklad, F. E. Jones, William Hu, V. Sotelo, Yaneicy Gonazalez Rojas, Jacobo E Mintzer, Crystal Flynn Longmire, KENNETH M. SPICER, Frank Tennigkeit, Andrea Pfeifer, Christine Vincenzetti, Fabien Monin, Gautam Maitra, Joseph O'Sullivan, Alex Teligladas, Ana Belen Díaz, Christophe Bintener, Cindy Birck, Dianne Gove, Georges Jean, Katherine Ellis, Stefanie Peulen, Eva Danasi, Georgios Vlachos, Nicolaos Scarmeas, Alexandre Mencik, Cynthia Ng, Hernàn Picard, Mats Ericson, Matt Gaunt, Nicolas Pourbaix, Rob Lenz, Rodolphe Eyraud, Ross McGarrity, Véronique Chauvet, Ala-Eddine Allouche, Béatrice Le Balanger, Bruno Dubois, Edith Benmansour, Francis Nyasse, Hicham Filali, Ihsen Youssef, Leslie Ameil, Marion Dubois, Nabila Lajaail, Nabila Nyasse, Nadja Younsi, Patrick Feukam Talla, Souza Benadjaoud, Stéphane Lehéricy, Tatiana Akake Beshelemu, Belén Garcia Alonso, Bet Molina, Ian Sherriff, Pedro Pesini, Pedro Tirado, Virgina Pérez, Alan McNeill, Alicia Gibson, Andrew S. 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RANDOLPH, Harald Hampel, Michael Ewers, John Harrison, Andrew Donaldson, Donna Cairney, Sheila MacFayden, Tracy Baird, Adrian Mander, Andrea Wadeson, Brian Tom, Costanza Di Fant, Gavin Lingiah, James Howlett, Keith Merle, Lisa Brown, Rebekah Davies, Simon White, Steven Hill, Farid Chekani, Jina Swartz, Letitia Reyniers, Rezaul Khandker, Tamara L. Connelly, Laurie Ryan, Elizabeth Jane Coulthard, James Selwood, Natalie Rosewell, Rebecca Cousins, Cynthia D. Duggan, Catriona McNeill, Derek Brown, Shona McKay, Alasdair Lawrie, Emma Darling, Julie Scott, Kirsten McClelland-Brooks, Justine M. Hudson, Kate Ferguson, Peter Connelly, Prasad Guntur Ramkumar, Tiffany Stewart, Ana Graf, Barbara Stolz, Dieter Nussher, Etienne Pigeolet, Giulia Lestini, Gwenaëlle Fillon, Ines Paule, Marianne Maman, Sema Cheyun, Stephan Korte, Yvonne Madawela, Jeffrey A. Kaye, Sana Akel, Baptiste Porte, Julien Dumurgier, Sandrine Indart, Yaël Slama, Alexandra Fayel, Gérald Luscan, Hannah Hurst, James Eshelby, Mariana Gameiro, Max Mirza, Olga Krylova, Olivier Drap, Paul Marrone, Rachel Schindler, Y. Brault, Ewa Iwaniuk, Magda Łapińska, Magdalena Maslowska, Jacek Dobryniewski, Michael Gold, Maciej Maciejowski, Christina Rabe, Enisa Alibasic, Friedemann Krause, Jason Hanon, Joanna Wright, Jyoti Srivastava, Maryline Simon, Richard Batrla‐Utermann, Silvia Barbara Schmid, Simone Wahl, Udo Eichenlaub, Verena Neuhold, Ingo Kilimann, Stefan Teipel, Clemens Peter, Dianne Stephanie Van Houdt, Edo Richard, Jordy Birahy, Marthe Smedinga, Reli Pascale, Sonja A. S. A Bemelmans, S. M. Beukers, Wim Van Oijen, Katarzyna Lucka, Konrad Rejdak, Aleksandra Stjepanovic-Agovic, Caroline Cohen, Cornelia Mockwitz, Frederic Delalonde, Isabelle Clavier, Jean-François Dedieu, Laurence Mazuranok, Nacera Hamdani, Nathalie Piton, Philippe Rocolle, Romain Hahn, Carlos Díaz, Estefanía Callado, Nina Coll, Nuria Subirats, Saira Ramasastry, Sandra Pla, Achim Fischer, Adam James Schwarz, Alex Bowtell, Antonella Chiucchiuini, Henrik Andersson, Melissa Naylor, Polyna Khudyakov, Rajan Perinpanayagam, Wei Zhong, Howard Feldman, Tristy Tara, Timo Grimmer, Carol Brayne, David Ash, Dennis Pai Chan, Emma Barham, Guy Casy, John O'Brien, Judith Wilson, Lesley Pilgrim, Michele K. York, Nadja Smailagic, Natassia F. Brenman, PETER THOMAS GEACH, Philippa Farmer, Renata Schaeffer, Richard Milne, Sally Atkinson, Sarah Findon, Sarah Taylor, Shirlene J. Badger, Susan H. Black, Tazuko Edwards, Will Clark, Zeynep Sahin, Babak Boroojerdi, Bernhard Greve, Daphne Derouane, David Marquet, Johannes Rolf Streffer, Katharina Angrosch, Mireille Delval, Peter Verplancke, Simon Dresse, Stefano Zanigni, Suzanne McCabe, Nick C Fox, Pawel Markiewicz, Joel Kramer, Sabrina J. Erlhoff, Michael Schaffer, Adam Waldman, Alan Kennedy, Andy Kodiak, Angela Noble, Anna Anderson, Anna Borthwick, A. J. Hall, Bill Bruce, Brian McTeir, Carol Di Perri, Cathie L. M. Sudlow, Chloe Kippen, Clare Dolan, Craig Ritchie, David Hill, David Matheson, Doug Young, Eirini Souri, Ellie Mcmaster, Emilie Delpon, Emma Law, Emma Munro, Fiona Campbell, Fiona Edler, Fiona Elizabeth Scott, Graciela Muniz Terrera, Hannah Jobse, Hazel Milligan, Hinesh Topiwala, Howard Marriage, Jean C. Manson, Jen Middleton, Joanna Swiderska, Joanna Wardlaw, Joanne MacConnell, Judi Syson, Julie Edwards, Kate Forsyth, Kathryn Carruthers, Katia Hervy, Katie M. Wells, Kristy Draper, Laura Doull, Laura Petrie, Lesley Niezynski, Lindsay Hampton, Loukia Koutsoventi, Lucy Stirland, Marise Bucukoglu, Molly Boughey, Natalie D Jenkins, Neil Duncan, Neil Fullerton, Neil Mitchell, Ray French, Rebecca Flory, Ruaridh Buchan, Rustam Al Shahi-Salman, Samuel Danso, Sarah Gregory, Sarah Sparks, Stina Saunders, Susan Shepherd, Tamlyn Watermeyer, Tom MacGillivray, Tom Russ, Tyler Saunders, Val Renton, Vikki Leslie, Alexander Dzerzga, Britta Doelle, Christel Gatzke, Clause Escher, Denise Schneider, Lena Sannemann, Manuela Thelen, Petra Schreiner-Kaub, Simone Stockter, Susan Thielking, Theresa Mueller, Frank Jessen, Andrea Toja, Elena Chipi, Lucia Farotti, Lucilla Parnetti, Owen Lancaster, Anthony J. Brookes, Brian Berry, Colin Veal, Dhiwagaran Thangavelu, Jon Sole, Marie Adams, Monika Maini, Nickie Ketcher, Nicola A Ketcher, Vagelis Ladas, Alexandra Agogue, Ana Campillo, Andreas Schmalz, Bianca Auschra, Blanche Pirotte, Christine Trombert, Daria Genaro, Elisa Canzoneri, Emiliano Albanese, Estefania Vilarino, Giovanni Battista Frisoni, Jennyfer Sturzmann, Margherita Mauri, Marina Boccardi, Mathilde Boillat, Maura Parapini, Monica Almici, Paulina Andryszak, Sven Haller, Tatjana Stevanovic, Christopher Kipps, Susan Jackson, Charlotte Frick, Henrik Zetterberg, Kaj Blennow, Linnea Petersson, Maria Berglund, Silke Kern, Alexandra Radford, Annalena Venneri, Joanne Sidebottom, Patrick Easton, Rosie Clegg, Walter Kullur, Tom Hartley, Amy Chinner, Antoniya Markova, Ash Sexton, Caroline Jenkins, Clare Mackay, Corinne Prescott, David Ruvolo, Delia Alexandra Gheorghe, Denis Murphy, Gem Pope, Gill Cane, Gill Wells, Ivan Koychev, Jasmine Blane, Jennifer A. Lawson, John Gallacher, Juliana Ballaminut, Justin Lowen, Karla H. Westphal, Katherine Shepherd, Kay McNamee, Leona Wolters, Michael Ben Yehuda, Natalie Morgan, Neil Buckholtz, Nyla Haque, Patricia Burton, Sarah Bauermeister, Sarah Hoosdally, Shona Forster, Tequila Osborne, Vanessa Raymont, Ann van den Eynde, Sebastiaan Engelborghs, Rik Vandenberghe, Carine Schildermans, Alle Meije Wink, André Van der Wal, Aniko Hazelebach, Anna Elisabeth Leeuwis, Casper de Boer, Fiona Heeman, Frederik Barkhof, Isadora Lopes-Alves, Jeroen van Leur, Lea ter Meulen, Lisa Vermunt, Luigi Lorenzini, Lyduine Eisa Collij, Mara ten Kate, Martijn Van Houten, Menno D. Stellingwerff, Merel Hermans, Michel Telkamp, Niels Prins, Philip Scheltens, Pieter Jelle Visser, Silvia Ingala, Wendy van Veen, Michelle McDonald, Clare J. Taylor, Genevieve Morrison, Mara Golemme, Paresh Malhotra, Sithuya Mahalingam, Christine van Broechhoven, Johan Goeman, Wendy Wittebolle · 发表于：EBioMedicine · 年份：2026 · DOI：10.1016/j.ebiom.2026.106133 · 被引用次数：6 · 研究领域：Cerebrospinal fluid and hydrocephalus、Fetal and Pediatric Neurological Disorders、Neurogenesis and neuroplasticity mechanisms

BACKGROUND: The glymphatic system plays a critical role in brain waste clearance and health. Diffusion tensor imaging along the perivascular space (DTI-ALPS) is an emerging approach to assess glymphatic function, but manual analysis is limited by its subjectivity and laboriousness in clinical practice. To address these challenges, we developed a deep learning-enhanced DTI-ALPS (dALPS) method that automates and enhances measurement of DTI-ALPS in large-scale cohorts, enabling us to uncover its genetic and environmental determinants. METHODS: We proposed an automated workflow combining convolutional neural network (CNN) and You Only Look Once (YOLO) for region-of-interest detection in DTI images. Using this method, we calculated dALPS index for over 65,000 participants from UK Biobank and multiple cohorts, and performed a genome-wide association study (GWAS). Additionally, we conducted transcriptome-wide association study (TWAS) and proteome-wide association study (PWAS) to explore the genetic and molecular underpinnings of glymphatic function. Associations between dALPS and demographic, lifestyle, and clinical traits were comprehensively evaluated. Mediation analysis was conducted to explore the potential mediating role of pharmacological treatments, including antidepressants and sleep medications, in the relationship between disease status and dALPS outcomes. FINDINGS: Our automated dALPS index showed excellent reliability and reproducibility compared to conventional manual t...