Post-infection disorders of gut-brain interaction: results of the Rome Foundation Global Epidemiology Study

作者：G Marasco, Max J. Schmulson, Uday C Ghoshal, Rutaba Khatun, Shrikant I Bangdiwala, Cesare Cremon, Olafur S Palsson, AD Sperber, Giovanni Barbara · 发表于：Gut · 年份：2026 · DOI：10.1136/gutjnl-2025-336509 · 被引用次数：3 · 研究领域：Gastrointestinal motility and disorders、Gut microbiota and health、Celiac Disease Research and Management

BACKGROUND: Post-infection disorders of gut-brain interaction (PI-DGBI) are a subset of chronic gastrointestinal disorders triggered by acute infectious gastroenteritis. These conditions impose a significant burden on patients' quality of life. OBJECTIVES: This study aimed to determine the prevalence of PI-DGBI and assess associated risk factors among participants in the Rome Foundation Global Epidemiology Study. DESIGN: Data were extracted from an online survey involving 54 127 participants across 26 countries. PI-DGBI were diagnosed based on self-reported gastrointestinal symptoms following acute gastroenteritis. Statistical analyses included multivariate logistic regression to identify factors associated with PI-DGBI and comparisons with DGBI not associated with infection. RESULTS: Of 21 713 individuals with at least one DGBI, 987 (10.5%) were classified as having PI-DGBI. PI-DGBI prevalence varied geographically, with the highest rates in Asia (7.1%) and Latin America (6.4%). Younger age, male sex, urban residence, anxiety and higher somatic symptom scores were positively associated with subjects reporting PI-DGBI, while female sex and rural living had negative associations. Subjects with PI-DGBI reported more severe psychological and physical health impairments and distinct gastrointestinal profiles, including higher rates of functional dyspepsia (32.2%), irritable bowel syndrome (23.5%) and anorectal disorders (35.3%). CONCLUSIONS: PI-DGBI represents a significant subse...