Abstract A081: Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined with Endovascular Treatment in ACute Ischaemic StrokE (RETRACE II): a randomised double-blind controlled multicentre phase II pilot study

作者：Lingling Ding, Wenjie Wang, Aoming Jin, Ting-yu Yi, Gaocai Zhang, Xinsheng Han, Wenhuo Chen, Hao Wang, Wanxing Ye, Yongjun Wang, Zixiao Li · 发表于：Stroke · 年份：2026 · DOI：10.1161/str.57.suppl_1.a081 · 研究领域：Transcranial Magnetic Stimulation Studies、Stroke Rehabilitation and Recovery、Spatial Neglect and Hemispheric Dysfunction

Background: Despite high recanalization rates with endovascular therapy, fewer than half of patients achieve functional independence, underscoring the need for adjunctive neuroprotective therapies. We aim to evaluate whether adjunctive Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS), initiated in the hyperacute phase after EVT, improves neurological outcomes. Methods: RETRACE II is a multicenter, randomized, double-blind, sham-controlled trial. Acute ischemic stroke patients who received EVT were randomly assigned (1:1) to either active LF-rTMS or sham stimulation. The LF-rTMS group received 1200 pulses of 1 Hz rTMS targeting the ipsilesional primary motor cortex, delivered twice daily for three consecutive days, starting within 24 hours of stroke onset. The primary outcome was early neurological improvement at 3 days post-treatment, defined as a ≥4-point decrease in NIHSS or NIHSS score of 0–1 from baseline. Key secondary outcomes included infarct volume on MRI at 7 days and the proportion of patients achieving an excellent recovery (modified Rankin Scale [mRS] 0–1) at 90 days. Safety endpoints included symptomatic intracranial haemorrhage (sICH), neurological deterioration (NIHSS increase ≥4). Findings: Sixty patients (mean age 64 years, 72% male) were enrolled. At 3 days post-stroke, the proportion of patients reaching the early neurological improvement was 70% in both groups, with no statistically significant difference observed after adjusting for ag...