Lipid metabolism and gallstone disease risk: a multicenter study

作者：Yi Jiang, Chunlan Wang, Yanmei Lou, Xianyan Zhang, Menglin He, Xuan Bai, Jing Luo, Wenqian Yu, Guoheng Jiang, Hongyu Li, Xin Wang, Yiting Xu, Linjun Xie, Guangcan Li, Xuefeng Shan, Yang Yi, Ling Zhang, Fei Li, Xin Wang · 发表于：Scientific Reports · 年份：2026 · DOI：10.1038/s41598-026-37603-x · 研究领域：Gallbladder and Bile Duct Disorders、Pancreatitis Pathology and Treatment、Kidney Stones and Urolithiasis Treatments

This study aimed to explore the associations between various lipid parameters and the risk of gallstone disease (GSD). A multicenter cross-sectional study was conducted to explore the associations between nine lipid parameters and the risk of GSD. Multivariable logistic regression models, adjusted for covariates, were employed to evaluate these associations. Stratified analyses by age and sex were performed to assess population-specific effects. Data from multiple centers were integrated using meta-analysis to generate pooled odds ratios with 95% confidence intervals. Trial Sequential Analysis (TSA) was implemented to determine the sufficiency of the sample size and the robustness of the associations under cumulative evidence conditions. This multicenter study included 580,935 participants, with a GSD prevalence of 7.43%. After adjusting for covariables, the combined multi-center results showed that total cholesterol, high-density and low-density lipoprotein cholesterol, and non-HDL cholesterol were negatively associated with GSD risk. In contrast, the Castelli risk index I and II, atherogenic coefficient, and atherogenic index of plasma were positively associated with the risk of GSD. Subgroup analyses and sensitivity analyses yielded consistent results. Stratified analysis revealed distinct lipid-gallstone associations between people with cholecystectomy and gallbladder stones. TSA revealed that the required amount of information has been achieved, and the results are concl...