Prevalence of Mood and Anxiety Disorders in Individuals at Clinical High Risk for Psychosis: A Comparison with Youth at Risk for Bipolar Disorder

作者：David Miklowitz, J. Addington, Danielle Denenny, Jamie Zinberg, Andrea A. Auther, Daniel H. Mathalon, Kristin Cadenhead, Michelle Friedman-Yakoobian, Scott Woods, Tyrone Cannon, Mary O'Brien, CARRIE E. BEARDEN · 年份：2026 · DOI：10.22541/au.176917688.86373945/v1 · 被引用次数：1 · 研究领域：Bipolar Disorder and Treatment、Schizophrenia research and treatment、Treatment of Major Depression

Background . Individuals who are at clinical high risk for psychosis (CHR-P) typically present with attenuated positive symptoms. Less is known about the frequencies, breadth, or impact of mood or anxiety disorders that co-occur with CHR-P conditions. Methods . In individuals who met the Structured Interview of Psychosis-Risk Syndromes Criteria for Prodromal Syndromes (N=198; mean age 16.3 + 2.7 yrs), we examined the frequency of mood and anxiety disorders prior to entry into a clinical trial. We compared this sample to youth at high risk for bipolar disorder (N = 127; mean age 13.2 + 2.6) who were also ascertained prior to a clinical trial. Results . Mood disorders were observed in 54.5% of individuals at CHR-P. Individuals with CHR-P and mood disorders had more severe positive and negative symptoms and lower global functioning compared to those at CHR-P without mood disorders. Comparable rates of major depressive disorder (46.5%) and anxiety disorder (67.7%) were observed in CHR-P individuals and youth at high risk for bipolar disorder (58.3% and 59.8%, respectively). With age covaried, individuals at CHR-P were more likely to have social anxiety disorder (24.2%) compared to youth at high risk for bipolar disorder (19.7%) (χ2(1) = 7.61, p = 0.006). Conclusions . Despite different methods of ascertainment, rates of mood and anxiety disorders were similar in these two high-risk populations. Transdiagnostic interventions targeting depression, anxiety, and social-occupational f...