Design of a bispecific peptide-nanozyme conjugate for cancer immunotherapy

作者：Danhong Chen, Ran Xu, Xiaoyun Ye, Youmei Xiao, Mengfan Wang, Wanqiong Li, Feiyu Luo, Xiaoshuang Niu, Xia Yang, Ye Su, Wenxuan Zeng, Ying Liu, Wenzhi Shang, Yang Li, Xin Zhao, J Hu, Xiaoshuang Chen, Xueqin Zhu, Xinghua Sui, Yanfeng Gao · 发表于：Cell Reports Medicine · 年份：2026 · DOI：10.1016/j.xcrm.2025.102568 · 被引用次数：4 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Cancer Immunotherapy and Biomarkers

T cell infiltration and activation in anti-PD-1-resistant tumor model. The BsPNEC platform integrates tumor-targeted delivery, magnetic resonance imaging (MRI) contrast capabilities, and robust inhibition of tumor growth. Our findings present a synergistic immunotherapeutic strategy that simultaneously skews immunosuppressive TME and amplifies T cell immune response.