Compartment-specific tumor-infiltrating immune cells and prognosis in breast cancer

作者：Aaron J. Bernstein, Renske Keeman, Amber N. Hurson, Fiona M. Blows, Manjeet K. Bolla, Jodi L. Miller, Roger L. Milne, Hugo Horlings, Alexandra J. van den Broek, Clara Bodelon, James M. Hodge, Alpa V. Patel, Lauren R. Teras, Federico Canzian, Rudolf Kaaks, Hermann Brenner, Ben Schöttker, Sabine Behrens, Jenny Chang-Claude, Tabea Maurer, Nadia Obi, Fergus J. Couch, H.Raza Ali, Carlos Caldas, Irene Andrulis, Gord Glendon, Anna Marie Mulligan, Wilma E. Mesker, Agnes Jager, Annette Heemskerk-Gerritsen, Peter Devilee, Scott M. Lawrence, Jolanta Lissowska, Karun Mutreja, Thomas Ahearn, Stephen Chanock, Máire A. Duggan, Diana Eccles, J. Louise Jones, Will Tapper, Antoinette Hollestelle, Maartje Hooning, John W.M. Martens, Carolien H. M. van Deurzen, Angela Cox, Simon S. Cross, Mikael Hartman, LI Jing-mei, Thomas Choudary Putti, Ute Hamann, Muhammad Rashid, Ania Jakubowska, Nicki J Camp, Melissa H. Cessna, Amy Berrington de González, Katarzyna Białkowska, J. Gronwald, Jan Lubiński, Siddhartha Yadav, Pietro Liò, Doug F. Easton, Mustapha Abubakar, Montse Garcia-Closas, Paul D.P. Pharoah, Marjanka K. Schmidt · 发表于：iScience · 年份：2026 · DOI：10.1016/j.isci.2026.114759 · 被引用次数：2 · 研究领域：Cancer Immunotherapy and Biomarkers、Immune cells in cancer、Single-cell and spatial transcriptomics

TIICs were associated with a poorer prognosis in ER-positive disease in multi-marker models. These results may have implications for breast cancer immunotherapy.