Apoptotic vesicles: from biological characteristics to clinical translational prospects

作者：Longbin Huang, Chen Kong, Mei-Feng Yang, Shuang Zhang, Ning-ning Yue, Yong Zhang, Cheng-mei Tian, Daoru Wei, Rui-yue Shi, Dingguo Zhang, Yu-jie Liang, Jun Yao, Li-sheng Wang, De-feng Li · 发表于：Journal of Translational Medicine · 年份：2026 · DOI：10.1186/s12967-025-07660-3 · 被引用次数：1 · 研究领域：Extracellular vesicles in disease、Phagocytosis and Immune Regulation、Cell death mechanisms and regulation

BACKGROUND: Apoptotic vesicles (apoVs), a specialized subtype of extracellular vesicles released during cellular apoptosis, play crucial roles in intercellular communication and immune regulation. In recent years, their functions in various physiological and pathological processes have garnered increasing attention. MAIN BODY: This review provides a comprehensive overview of the biological characteristics, formation mechanisms, and functional implications of apoVs in various diseases. It particularly emphasizes the potential clinical applications of apoVs in diagnostics and therapeutics. By integrating the latest research advancements, the review analyzes the molecular cargo packaging mechanisms of apoVs and their impact on functionality, assessing their prospects as drug carriers and immune modulators. CONCLUSIONS: By synthesizing existing research findings, this review aims to provide a systematic theoretical foundation and practical strategies for both fundamental research and clinical translation of apoptotic vesicles. Further investigation into apoptotic vesicles is expected to offer novel insights and approaches for the diagnosis and treatment of various diseases.