Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

作者：Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yujie Qin, Junmin Zhang, Chaohua Tang · 发表于：Animal Research and One Health · 年份：2026 · DOI：10.1002/aro2.70051 · 被引用次数：1 · 研究领域：Ferroptosis and cancer prognosis、Selenium in Biological Systems、Bone and Dental Protein Studies

ABSTRACT Selenium (Se) is an essential trace element with multiple biological functions, including anti‐inflammatory, antioxidant, growth‐regulating, and immunomodulatory functions. Dysregulation of the arachidonic acid (AA) metabolism‐ferroptosis‐inflammation axis is associated with the progression of intestinal inflammatory diseases, suggesting that its nutritional regulation holds potential for health management. This study explored how selenomethionine (Se‐Met), a bioactive dietary form of Se, regulates this axis to promote gut health using a murine model of AA‐induced colitis. C57BL/6J mice were pre‐fed a diet with Se‐Met (0.2 or 1.0 mg/kg) for 6 weeks, followed by intragastric administration of AA (30 mg/day) for 4 weeks. The results showed that excessive AA intake induced colitis, characterized by intestinal inflammation and barrier dysfunction. Se‐Met supplementation alleviated colitis symptoms, improved intestinal barrier function, and inhibited inflammation. Mechanistically, Se‐Met enhanced antioxidant defenses by upregulating selenoprotein expression, modulated AA metabolism to reduce the production of pro‐inflammatory oxylipins, and inhibited the ferroptosis signaling pathway. Transcriptomics analysis revealed systemic regulatory effects of Se‐Met on pathways related to inflammation and lipid metabolism, whereas 16S rRNA sequencing showed that Se‐Met remodeled the gut microbiota. These findings highlight that Se‐Met alleviates colitis through multi‐targeted regula...