Tissue factor activity and 1-year mortality in patients with active cancer and acute ischemic stroke: findings from the SCAN study

作者：Yasufumi Gon, Tomohiro Kawano, Takaya Kitano, Hiroshi Yamagami, Soichiro ABE, Hiroyuki Hashimoto, Nobuyuki Ohara, Daisuke Takahashi, Yuko Abe, Tsutomu Takahashi, Junji Takasugi, Hideaki Kanki, Tsutomu Sasaki, Manabu Sakaguchi · 发表于：Research and Practice in Thrombosis and Haemostasis · 年份：2026 · DOI：10.1016/j.rpth.2026.103347 · 被引用次数：2 · 研究领域：Blood Coagulation and Thrombosis Mechanisms、S100 Proteins and Annexins、Protease and Inhibitor Mechanisms

Background: Tissue factor (TF), the cellular receptor for plasma factor (F)VII/FVIIa and a key initiator of the extrinsic coagulation pathway, plays a central role in cancer-associated thrombosis. However, its prognostic significance in patients with active cancer (AC) and acute ischemic stroke (AIS) remains unclear. Objectives: This study evaluates the association between plasma TF activity and outcome in patients with AC and AIS. Methods: We analyzed data from the SCAN study, a prospective, multicenter, observational study conducted in Japan. Blood samples were obtained immediately after admission, prior to any stroke treatment. TF activity was measured using a chromogenic assay. Patients were dichotomized at the median TF activity. Kaplan-Meier survival and Cox proportional hazards models were used to assess 1-year mortality, and restricted cubic spline analysis was conducted to explore nonlinear associations between TF activity and mortality. Results: = .011). Conclusion: Elevated TF activity was independently associated with 1-year mortality in patients with AC and AIS. TF activity represents a potential prognostic biomarker in this population.