Multivariable analysis of bone mass reduction risk prediction and anxiety status in male HIV/AIDS patients

作者：Keke Hou, Tao Li, Shuyin Zhang, Jianglin He, Ting Wan, Yueqin Gao, Lei Xiong, Siqi Fu, Na Zhang, Guocheng Zhao · 发表于：Frontiers in Reproductive Health · 年份：2026 · DOI：10.3389/frph.2025.1703420 · 被引用次数：1 · 研究领域：HIV-related health complications and treatments、HIV Research and Treatment、HIV/AIDS oral health manifestations

Background The psychological health issues and bone mass reduction observed in patients with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) have attracted increasing public attention. This study aimed to assess anxiety status in male HIV/AIDS patients, develop a risk prediction model for bone mass reduction, identify major contributing factors, and evaluate the predictive performance of the model. Methods This cross-sectional study included 243 male HIV/AIDS inpatients who underwent dual-energy x-ray absorptiometry (DXA) at the Chengdu Public Health Clinical Medical Center, China, between March 2023 and December 2024. Clinical and laboratory data were retrospectively extracted from the hospital electronic medical record system, whereas anxiety information was prospectively assessed during hospitalization using the 14-item Hamilton Anxiety Rating Scale (HAM-A). Univariate and multivariate logistic regression analyses were performed to identify independent predictors of bone mass reduction, and a nomogram model was constructed and validated using the area under the curve (AUC), concordance index (C-index), Hosmer–Lemeshow test, and decision curve analysis (DCA). Results 1. HAM-A assessment of the 243 patients showed that 135 (55.56%) were likely to have anxiety, 73 (30.04%) were confirmed to have anxiety, 29 (11.93%) had marked anxiety, and 6 (2.47%) were likely to have severe anxiety. 2. Univariate analysis revealed that six variables—age, body ma...