Managing Pregnancy in the Presence of Rheumatic Heart Disease and Antiphospholipid Syndrome

作者：S. Zahid, Mannal Ahmed, Reema Qayoom, Hannah Asghar · 发表于：JACC Case Reports · 年份：2026 · DOI：10.1016/j.jaccas.2025.106399 · 研究领域：Cardiovascular Issues in Pregnancy、Rheumatoid Arthritis Research and Therapies、Pregnancy and Medication Impact

BACKGROUND: Rheumatic heart disease remains a major cause of maternal morbidity and mortality in low- and middle-income countries. The coexistence of severe mitral stenosis (MS) and antiphospholipid syndrome presents an exceptionally high-risk clinical scenario requiring multidisciplinary management. CASE SUMMARY: , and she delivered a healthy baby at term without complications. DISCUSSION: Pregnancy in women with rheumatic MS and antiphospholipid syndrome demands coordinated care to balance hemodynamic and thrombotic risks while ensuring fetal safety. TAKE-HOME MESSAGE: Timely cardiac intervention, multidisciplinary collaboration, and individualized care enable favorable maternal and fetal outcomes in complex high-risk pregnancies.