Altered static and dynamic amplitude of low-frequency fluctuations in acute carbon monoxide poisoning patients: a resting-state fMRI study

作者：Shenghai Wang, Tianze Sun, Wenxuan Han, Xiaoying Lin, Jiaqi Zhang, Yihao Peng, Mingyue Ma, Wei Sheng, Ming Zhang, Haining Li · 发表于：Frontiers in Neuroscience · 年份：2026 · DOI：10.3389/fnins.2025.1695556 · 被引用次数：1 · 研究领域：Heme Oxygenase-1 and Carbon Monoxide、Traumatic Brain Injury Research、Intracerebral and Subarachnoid Hemorrhage Research

Objective This study aimed to investigate alterations in brain activity due to acute carbon monoxide poisoning (ACOP) and their relationship with clinical manifestations using static and dynamic amplitude of low-frequency fluctuation (ALFF) analyses. Methods Resting-state functional magnetic resonance imaging (fMRI) and clinical data were obtained from 31 ACOP patients and 28 healthy controls. The static ALFF value and dynamic ALFF variability were measured and compared between groups. Partial correlation analysis explored the relationships between changes in ALFF and clinical features in ACOP patients. Results ACOP patients exhibited increased dynamic ALFF in the bilateral superior frontal gyrus (SFG) and left middle frontal gyrus (MFG) and decreased static ALFF in the left middle occipital gyrus (MOG) compared to controls. Aberrant dynamic ALFF in the left SFG and MFG was negatively correlated with MoCA-B scores ( r = −0.430, p = 0.036; r = −0.439, p = 0.032). Conclusion ACOP patients exhibited abnormal instability in intrinsic brain activity, particularly in prefrontal areas, where temporal variability in local brain activity correlates with cognitive performance. This study highlights the value of combined static and dynamic ALFF approaches in understanding brain disturbances caused by CO exposure, providing new insights into the neuropathological mechanisms of ACOP.