Supplementary Text 1 from Development and Prospective Validation of a Cell-free DNA–Based Model for the Early Detection of Pancreatic Cancer

作者：Xiuchao Wang, Hongwei Wang, Meng Zhang, Huikai Li, Yang Liu, Hanfei Huang, Jinlong Pei, Jing Huang, Fenglin Zang, Yanhui Zhang, Xingyun Chen, Song Gao, Tiansuo Zhao, Jian Wang, Weidong Ma, Yuexiang Liang, Shangheng Shi, Shuo Li, Wei Li, Tianxing Zhou, Ying Zhang, Xiaonan Cui, Zhaoxiang Ye, Yan Sun, Li Peng, Xiao Hu, Zhitao Li, Hao Zhang, Dongqin Zhu, Shuang Chang, Jun-Ye Zhang, Ruowei Yang, Hua Bao, Xue Wu, Yang Shao, Jun Yu, Chuntao Gao, Yunfeng Cui, Jihui Hao · 年份：2026 · DOI：10.1158/2159-8290.31047072 · 被引用次数：1 · 研究领域：Pancreatic and Hepatic Oncology Research、Cancer Genomics and Diagnostics、Single-cell and spatial transcriptomics

<p>This document provides detailed descriptions of patient recruitment procedures for the case-control cohort, methods for genomic feature extraction, model construction and training, statistical analyses, feature importance assessment, and both in silico and experimental evaluations of the limit of detection. It also includes the design of the prospective screening cohort and comprehensive clinical information on the pancreatic cancer–related cases identified therein.</p>