Figure S14 from EML4−ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis

作者：Alberto Diaz-Jimenez, Emily G. Shuldiner, Kálmán Somogyi, Karen Y. Shih, Óscar González-Velasco, Mulham Najajreh, Stewart J. Kim, Filiz Akkas, Christopher W. Murray, Laura Andrejka, Min K. Tsai, Benedikt Brors, Ilse Hofmann, Smruthy Sivakumar, Saumya D. Sisoudiya, Ethan S. Sokol, Huiwen Cai, Dmitri A. Petrov, Monte M. Winslow, Rocı́o Sotillo · 年份：2026 · DOI：10.1158/2159-8290.31047258 · 研究领域：Lung Cancer Treatments and Mutations、Lung Cancer Research Studies、Cancer Genomics and Diagnostics

<p>Supplementary Figure 14 shows the the response of EML4-ALK-driven lung tumors to lorlatinib in vivo, including tumor volume measured by µCT and histology, adaptively sampled mean tumor size of tumor suppressor knockouts, Kolmogorov–Smirnov (KS) distance between the cumulative density plots of the lorlatinib-treated and the “shrunk” vehicle-treated sgInert tumor sizes, estimated optimal shrinkage values of sgInert tumors, and the impact of each tumor suppressor targeting vector on lorlatinib response.</p>