Probiotic therapy as adjuvant for allergic rhinitis: an overview of systematic reviews and meta-analyses

作者：Zhuang Wang, Yongfu Song, Xue Liang, Na Wang, Dongze Li, Xiaofei Xie, Bo Tian, Yongji Wang · 发表于：Frontiers in Medicine · 年份：2026 · DOI：10.3389/fmed.2025.1711096 · 被引用次数：2 · 研究领域：Probiotics and Fermented Foods、Allergic Rhinitis and Sensitization、Pediatric health and respiratory diseases

Objective: This study aims to provide an overview of systematic reviews and meta-analyses on probiotic adjuvant therapy for allergic rhinitis, with the goal of offering evidence-based support for clinical practice and decision-making. Methods: A comprehensive search was performed in PubMed, Embase, Cochrane Library, Web of Science, CNKI, VIP, WANFANG, and CBM databases from their inception to 5 July 2025, to identify systematic reviews and meta-analyses on probiotic adjuvant therapy for allergic rhinitis. Constructing a literature overlap matrix and calculating the adjusted overlap area for assessing duplication rates in source literature. ROBIS, AMSTAR-2, PRISMA 2020, and GRADE were used to assess bias risk, methodological/reporting quality, and evidence certainty. Quantitative and qualitative analyses of primary outcomes provided comprehensive insights. Results: Fifteen systematic reviews and meta-analyses were included; the adjusted overlap area, calculated from the literature overlap matrix, was 16.939%, all demonstrating low bias risk. Methodological quality assessment identified 9 high-, 5 low-, and 1 critically low-quality study. The evaluation of reporting quality showed 7 high-, 7 moderate-, and 1 low-quality study. Evidence certainty grading yielded 11 high-, 37 moderate-, 35 low-, and 17 critically low-quality outcomes. Quantitative analysis confirmed that probiotic adjunct therapy significantly reduced eosinophil counts in patients with allergic rhinitis. Qualitat...