Figure S5 from EML4−ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis

作者：Alberto Diaz-Jimenez, Emily G. Shuldiner, Kálmán Somogyi, Karen Y. Shih, Óscar González-Velasco, Mulham Najajreh, Stewart J. Kim, Filiz Akkas, Christopher W. Murray, Laura Andrejka, Min K. Tsai, Benedikt Brors, Ilse Hofmann, Smruthy Sivakumar, Saumya D. Sisoudiya, Ethan S. Sokol, Huiwen Cai, Dmitri A. Petrov, Monte M. Winslow, Rocı́o Sotillo · 年份：2026 · DOI：10.1158/2159-8290.31047243 · 研究领域：Microtubule and mitosis dynamics、Lung Cancer Treatments and Mutations、Genomic variations and chromosomal abnormalities

<p>Supplementary Figure 5 shows the schematic of Lenti-sgTSG75-sgV1/Cre and Lenti-sgTSG75-sgV3/Cre pools, tumor initiation in Cas9-negative mice to determine the representation of Lenti-sgRNA/Cre vectors, and additional data from broader screen of tumor suppressor function in V1- and V3-driven lung cancer including tumor burden, tumor number and effect.</p>