Fibronectin-Based Skin Care Regimens for Skin Recovery After Intense Pulsed Light Therapy: A Split-Face Study

作者：H. Feng, Lan Ge, Ge Shi, Shiqi Yu, X T Wang, Xiaowei Li, Wen Si, Linshan Wu, Zhen Yi, Xuesong Xian, Xiaoyan Fu, Baihui Zhang, Jinyin Liang, Hongling Zhu, L. Ye · 发表于：Clinical Cosmetic and Investigational Dermatology · 年份：2026 · DOI：10.2147/ccid.s564788 · 被引用次数：1 · 研究领域：Dermatologic Treatments and Research、Laser Applications in Dentistry and Medicine、Photodynamic Therapy Research Studies

Purpose: Intense pulsed light (IPL) treatment may cause transient erythema, dryness, and barrier dysfunction, highlighting the need for effective postprocedural care. This study aimed to assess the efficacy and safety of a fibronectin-containing skincare regimen in restoring skin barrier function and relieving these IPL-related manifestations. Patients and Methods: In this 28-day, split-face study, 32 healthy female participants undergoing IPL treatment applied a fibronectin-containing serum to one side of the face and a control serum to the opposite side. Skin hydration, transepidermal water loss (TEWL), erythema, and radiance were evaluated at baseline, immediately post-IPL, and on days 3, 7, and 28. Results: Compared to the control, the fibronectin-treated side showed significantly greater improvements in skin hydration (P < 0.01) and significantly lower TEWL on days 3 (P < 0.05), 7 (P < 0.01), and 28 (P < 0.01). By days 7 and 28, skin radiance and erythema also improved more significantly (P < 0.01). Both dermatologist and participant assessments confirmed the superior efficacy of the fibronectin serum. No adverse events were rePorted. Conclusion: Post-IPL aPPlication of a fibronectin-containing serum effectively imProves skin hydration, reduces barrier dysfunction and erythema, and enhances radiance with good tolerability. These findings suPPort its Potential utility in Post-IPL skincare regimens.