Magnetically Driven Lasing Microrobots for Precise Photodynamic Therapy

作者：Xiaoniu Guo, Guocheng Fang, Ningyuan Nie, Po-Hao Tseng, Weian Wang, Zhiyi Yuan, Xiaoxue Xu, Fei Hu, Niancai Peng, Yu-Cheng Chen · 发表于：ACS Nano · 年份：2026 · DOI：10.1021/acsnano.5c15360 · 被引用次数：1 · 研究领域：Micro and Nano Robotics、Orbital Angular Momentum in Optics、Space Satellite Systems and Control

Photodynamic therapy (PDT) is an emerging approach for tumor treatment, valued for its noninvasive and stimuli-responsive properties. However, its therapeutic efficacy is often constrained by unintended damage to healthy tissues, largely due to the strong scattering of pump light within biological media. In this study, we present a magnetically driven lasing microrobot as an effective light source for high-precision localized PDT. The microrobots were constructed from polystyrene microspheres doped with Nile Red and magnetic particles. When pumped with 530 nm light, these microrobots emit strong coherent whispering-gallery-mode (WGM) lasers at approximately 650 nm, matching the absorption of chlorin e6. A 20 μm microrobot demonstrated a lasing threshold of 52.1 μJ mm –2 and a motion velocity of 78.5 μm s –2 in biological media. Theoretically, the output power of the microrobot can meet the energy requirements for PDT treatment, while its illumination range reaches 35.1 μm. Leveraging its motion capabilities, the microrobot can navigate to targeted tumor sites on demand, enabling the precise ablation of tumor cells. PDT efficacy was validated using intestine-on-a-chip models and three-dimensional (3D) intestinal tumor spheroids. Results showed that the spatial resolution for tumor cell ablation reached 651.3 μm 2 in tumor spheroids, highlighting a significant improvement in therapeutic accuracy over conventional PDT approaches. This work integrates microlasers with robotic tec...