Prevalence of MASLD and fibrosis assessed by transient elastography in U.S. adolescents: insights from NHANES 2017-2023

作者：Jialin Wu, Junlong Huang, S. Cao, Yang Lyu, Peiyao Yu, Tiejun Feng, Bonan Chen, Fuda Xie, Ge Zhang, Zhuang Kangmin, A. Li, Ka Fai To, Wei Kang · 发表于：Diabetology & Metabolic Syndrome · 年份：2025 · DOI：10.1186/s13098-025-02024-9 · 被引用次数：2 · 研究领域：Liver Disease Diagnosis and Treatment、Nutrition and Health in Aging、Liver Diseases and Immunity

BACKGROUND/AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common but understudied disease in adolescents. We aimed to estimate the updated prevalence of MASLD and related fibrosis among US adolescents using transient elastography. METHODS: This study analyzed data from the National Health and Nutrition Examination Survey 2017 to March 2020 and August 2021 to August 2023 among adolescents ages 12-19 years. Steatotic liver disease was assessed using the median controlled attenuation parameter (CAP) and fibrosis by median liver stiffness measurement. RESULTS: A total of 2588 participants were included in the analysis (mean [SD] age, 15.4 [2.3] years; 1366 male participants [52.8%]). The overall age-adjusted prevalence of MASLD was 21.0% (95% CI: 19.1-23.0) using a CAP threshold of ≥ 248 dB/m and 16.1% (95% CI: 14.4-17.8) using ≥ 263 dB/m. The prevalence of MASLD-related fibrosis was 9.0% and 9.7% using CAP thresholds of 248 dB/m and 263 dB/m, respectively. Higher prevalence of MASLD and fibrosis was observed among adolescents with overweight, obesity, and prediabetes. Between the two survey cycles, the age-standardized prevalence of MASLD remained stable, with a non-significant decline observed in the prevalence of fibrosis. Multivariable analysis identified male sex, non-Hispanic Asian ethnicity, increased waist circumference, overweight, and obesity as independent risk factors for MASLD, while waist circumference was the only independent factor ass...