Features of IgG4-related sclerosing mesenteritis: A Chinese cohort study and literature review

作者：Jialei Zhang, Yuxue Nie, Jingna Li, Nianyi Zhang, Xinli Yang, Jialing Jiang, Yifei Wang, Qinhuan Luo, Jiaxin Zhou, Linyi Peng, Wen Zhang · 发表于：Rheumatology and Immunology Research · 年份：2025 · DOI：10.1515/rir-2025-0026 · 被引用次数：3 · 研究领域：IgG4-Related and Inflammatory Diseases、Liver Diseases and Immunity、Neuroendocrine Tumor Research Advances

Abstract Objectives This study aimed to summarize the features of IgG4-related sclerosing mesenteritis (IgG4-SM) based on both our large prospective IgG4-related disease (IgG4-RD) cohort and literature-reported IgG4-SM cases. Methods We applied a mixed-methods approach, integrating data from 29 patients with IgG4-SM and 87 matched IgG4-RD patients without mesenteritis, all enrolled in a prospective cohort of IgG4-RD from Peking Union Medical College Hospital (PUMCH) since 2011. Additionally, we included 32 IgG4-SM cases reported in public databases since 2011. Demographic, clinical, laboratory, imaging and treatment data were systematically compared. Results Compared with IgG4-RD without mesenteritis, IgG4-SM predominantly affected elderly males and accompanied with more organ involvement ( P = 0.019) and elevated responder index (RI) scores and Physician Global Assessment (PGA) scores ( P = 0.005 and P = 0.018, respectively). Compared to the literature-reported cases, IgG4-SM patients in our cohort exhibited a lower prevalence of abdominal pain ( P < 0.001) but a higher frequency of submandibular gland ( P < 0.001) and lacrimal gland enlargement ( P < 0.001). Imaging features included a spectrum of mesenteric abnormalities, ranging from misty opacities to soft-tissue masses on computed tomography (CT), with significantly increased 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake on positron emission tomography-computed tomography (PET-CT). Despite divergent treatments (gl...