Motor band sign in 18F-FDG PET/CT studies: a biomarker of degenerative upper motor neuron disease? A study of three cases and literature review

作者：Mariano Ruiz-Ortiz, Jesús Esteban‐Pérez, Adolfo Gómez‐Grande, E. Martínez-Albero, Julián Benito‐León · 发表于：Neurología (English Edition) · 年份：2025 · DOI：10.1016/j.nrleng.2025.501931 · 被引用次数：1 · 研究领域：Amyotrophic Lateral Sclerosis Research、Genetic Neurodegenerative Diseases、Peripheral Neuropathies and Disorders

• The lack of biomarkers represents an obstacle to the diagnosis of motor neuron diseases. • We present 3 cases of motor neuron disease showing hypometabolism around the Rolandic fissure in the brain 18 F-FDG PET study. • The literature suggests that the motor band sign is a biomarker of upper motor neuron degeneration. • Further studies are needed to confirm its clinical value and its possible inclusion as diagnostic criterion. Motor neuron diseases (MND) encompass conditions like amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS), marked by progressive degeneration of upper and/or lower motor neurons. The identification of specific biomarkers is crucial to reduce diagnostic delays. This study presents three clinical cases evaluated at the Hospital Universitario 12 de Octubre, where the motor band sign on brain 18 F-FDG PET/CT aided the diagnosis of MND. The studies were conducted using a SIEMENS Biograph True Point 6, with a review of relevant literature. In all three patients, PET/CT revealed hypometabolism in the prerolandic region, indicative of the motor band sign, contributing to the diagnosis of PLS or ALS. The motor band sign on 18 F-FDG PET/CT emerges as a potential marker of upper motor neuron involvement, though the heterogeneity of MNDs and variability across studies call for further research to establish its specificity and sensitivity. The motor band sign on 18 F-FDG PET/CT is a promising biomarker for MNDs, although further studies are req...