Beyond the Usual Suspects: RSV Infection in Patients With Hematological Malignancies Compared to Influenza and SARS‐COV‐2—A Report From the EPICOVIDEHA/EPIRESEHA Registry

作者：Jon Salmanton‐García, Francesco Marchesi, Milan Navrátil, Iker Falces‐Romero, Maria Ilaria Del Principe, J. Labrador, Klára Piukovics, Verena Petzer, Monika Biernat, Michail Samarkos, Dario Leotta, Nicola Fracchiolla, Anna Dąbrowska‐Iwanicka, Antonio Roig Vena, Benjamín Víšek, Yavuz M. Bilgin, Jens Van Praet, Mario Virgilio Papa, Inmaculada Heras Fernando, Francesca Farina, Ľuboš Drgoňa, Josip Batinić, B Weinbergerová, Nurettin Erben, Joanna Drozd‐Sokołowska, Patricia García‐Ramírez, Annarosa Cuccaro, Martin Čerňan, Nicola Sgherza, Tobias Lahmer, D. C. Vinh, Gaëtan Plantefeve, Alberto López‐García, Chiara Cattaneo, Nikola Pantić, С. Н. Хостелиди, Julio Dávila‐Valls, Andrés Soto‐Silva, László Imre Pinczés, Ferenc Magyari, Reham Khedr, Michelina Dargenio, Martijn Bakker, И. О. Стома, Carolina Garcia‐Vidal, Ildefonso Espigado, Claudio Cerchione, Caterina Buquicchio, Zlate Stojanoski, Gabriele Magliano, Stefanie K. Gräfe, Avinash Aujayeb, Lucia Prezioso, Vladimir Otašević, Maria Merelli, Erica Mackenzie, Andreas Glenthøj, Eleni Gavriilaki, Noha Eisa, Mario Delia, Alessandro Busca, Ahlam Almasari, Tatjana Adžić‐Vukičević, Ivana Urošević, Uluhan Sili, Carolina Miranda‐Castillo, Gustavo‐Adolfo Méndez, Stef Meers, Monia Marchetti, Nicola Coppola, Gökçe Melis Çolak, Darko Antić, Ditte Stampe Hersby, Pellegrino Musto, Milche Cvetanoski, Martin Schönlein, Tommaso Francesco Aiello, Elena Arellano, Davide Nappi, Sonia Martín‐Pérez, Mirjana Mitrović, Raúl Córdoba, Romane Prin, Marta Callejas‐Charavia, Gina Varricchio, Martina Bavastro, Alessandro Limongelli, Amalia Anastasopoulou, Alessandra Romano, Dominik Wolf, Kevin Nguyen, Lukas van den Ven, Alessia Di Pilla, Antonio Giordano, Oliver A. Cornely, Livio Pagano · 发表于：American Journal of Hematology · 年份：2025 · DOI：10.1002/ajh.70166 · 被引用次数：2 · 研究领域：Respiratory viral infections research、COVID-19 Clinical Research Studies、Pneumonia and Respiratory Infections

Respiratory syncytial virus (RSV) is a major cause of acute respiratory infections and seasonal hospitalisations, particularly among immunocompromised adults [1]. In patients with hematological malignancies, RSV can cause severe complications, including pneumonia, respiratory failure, and death, especially in those with lymphopenia, recent HSCT, or comorbidities [2]. Although antivirals, monoclonal antibodies, and vaccines exist for other high-risk groups, their efficacy in this population remains uncertain [3]. Screening and diagnostic protocols are inconsistent, treatments are often empiric, and hematological patients are largely excluded from clinical trials. Moreover, comparative data versus influenza and SARS-CoV-2 are limited, impeding the development of targeted, evidence-based prevention and management strategies for this vulnerable group [4]. This study used the EPICOVIDEHA/EPIRESEHA registry [5] to describe RSV infection in adults with hematological malignancies (Jan 2023–Dec 2024), comparing it with influenza and SARS-CoV-2. Data were collected via the international registry (NCT04733729), with ethical approval from Fondazione Policlinico Gemelli (ID 3226); consent was waived due to anonymization. Eligible participants were adults (≥ 18 years) with laboratory-confirmed RSV and active hematological malignancy treatment within the past 5 years. Exclusions were benign hematologic conditions, solid tumors, age < 18, treatment-free > 5 years, or RSV diagnosis based only...