Phosphorothiolation of Benzylic C(sp 3 )–H via EnT-Mediated Radical–Radical Cross-Coupling

作者：Pengbo Zhang, Xinyi Guo, Mengke Yang, Longyu Wang, Yuzhen Gao · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c04989 · 被引用次数：5 · 研究领域：Radical Photochemical Reactions、Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods

Direct phosphorothiolation of benzylic C(sp 3 )–H bonds remains underexplored. Herein, we report an energy transfer (EnT)-mediated method that achieves this via controlled radical–radical cross-coupling, using inexpensive K 2 S 2 O 8 as both an oxidant and a hydrogen atom transfer (HAT) reagent. This strategy eliminates prefunctionalization steps, demonstrates excellent chemoselectivity, and provides an atom- and step-economical route to diverse alkyl phosphorothioate compounds.