An mHealth (Mobile Health) Intervention for Smoking Cessation in People With Tuberculosis

作者：Maham Zahid, Fathima Rahman, Mahmoud Danaee, Shakhawat Hossain Rana, Asiful Chowdhury, Saeed Ansaari, Ai Keow Lim, Melanie Boeckmann, S. Parrott, J Li, Amina Khan, Rumana Huque, John D. Norrie, Kamran Siddiqi · 发表于：JAMA · 年份：2025 · DOI：10.1001/jama.2025.20765 · 被引用次数：7 · 研究领域：Tuberculosis Research and Epidemiology、Mobile Health and mHealth Applications、Medication Adherence and Compliance

Importance: Smoking worsens outcomes in people with tuberculosis (TB), while quitting hastens recovery. Objective: To assess the effectiveness of a mobile health (mHealth) intervention for achieving self-reported continuous tobacco abstinence at 6 months, supported by biochemical verification at 6 months, compared with usual care in people with TB. Design, Setting, and Participants: Multicenter, cluster randomized clinical trial conducted between September 18, 2023, and January 2, 2025, randomizing (2:1) 27 TB clinics in Bangladesh and Pakistan to mHealth or usual care groups. The follow-up was 6 months. Participants were eligible if they were 15 years or older, had been diagnosed with drug-sensitive pulmonary TB in the past 4 weeks, smoked daily, were willing to quit, and had access to mobile phones. Intervention: The mHealth group (n = 720) received text messages throughout TB treatment, daily for 2 months then monthly for 4 months, encouraging tobacco cessation. The usual care group (n = 360) received written information on tobacco cessation. Main Outcomes and Measures: The primary outcome was self-reported continuous abstinence at 6 months, verified biochemically using carbon monoxide breath test at 6 months. Secondary outcomes included self-reported point abstinence at 9 weeks and 6 months, TB treatment adherence (days receiving TB treatment), TB treatment success (cured + completed treatment), TB treatment failure, TB treatment default (interruption of TB treatment for ...