Novel Blood-Based Liquid Biopsy Approaches in Hepatocellular Carcinoma

作者：Namrata Anand, Sulin Wu, Zhoubo Guo, Marcos Santiago Figueroa, Lauren Jung, Mingyang Li, Irun Bhan, Joseph W. Franses · 发表于：JCO oncology advances. · 年份：2025 · DOI：10.1200/oa-25-00132 · 被引用次数：1 · 研究领域：Cancer Genomics and Diagnostics、Hepatocellular Carcinoma Treatment and Prognosis、Cancer Cells and Metastasis

Hepatocellular carcinoma (HCC) has an increasing incidence and global mortality burden. Diagnosis and management of HCC has improved over the years, and innovative molecular tests are emerging as promising biomarkers for prognosis and response prediction. Conventional circulating protein biomarkers, such as alpha-fetoprotein, are widely used but have limited sensitivity and specificity. Liquid biopsy approaches rely on the detection and characterization of additional blood-borne analytes—including circulating tumor-derived DNA genomic or epigenomic features, exosomes, circulating tumor cells, and others. These methods—potentially in combination with conventional blood-based analytes—have the potential to significantly improve early detection, prognostication, and treatment monitoring. In this review, we highlight recent nongenomic blood-based liquid biopsy approaches and their clinical applications in HCC.