Maternal and neonatal outcomes after infection with monkeypox virus clade I during pregnancy in DR Congo: a pooled, prospective cohort study

作者：Emmanuel Hasivirwe Vakaniaki, Isaac Barhishindi, Ange Mubiala, Espoir Bwenge Malembaka, Lydia Braunack-Mayer, Bruce Nganga, Sabin S. Nundu, Isabel Brosius, Stefanie Bracke, Eugene Bangwen, Elise De Vos, Robert Colebunders, Mireille Ngale, Gabriel Makabu Kayembe, Christian Tshongo, Ali Dilu, Célestin Tshimanga, Jean-Luc Biampata, Patrick Musole Bugeme, Nsengi Ntamabyaliro, Bruce Kirenga, Misaki Wayengera, Joseph Nelson Siewe Fodjo, David Lupande Mwenebitu, Anne W. Rimoin, Tony Wawina-Bokalanga, Koen Vercauteren, Daniel Mukadi-Bamuleka, Jean-Jacques Muyembe-Tamfum, Susanne Krasemann, Jason Kindrachuk, Andrew S. Azman, Véronique Nussenblatt, Ian Crozier, Lori E. Dodd, Olivier Tshiani-Mbaya, Steve Ahuka Mundeke, Adrienne Amuri-Aziza, Jean-Claude Makangara-Cigolo, Fiston Mpinda-Isekusu, Eddy Kinganda-Lusamaki, Raphaël Lumembe-Numbi, Yves Mujula, Papy Munganga, Jean-Claude Tshomba, Sarah Houben, Christophe Van Dijck, Nicole A. Hoff, Sydney Merritt, Martine Peeters, Richard Kojan, Léandre Mutimbwa-Mambo, Jenestin Babingwa Munga, Steeven Bilembo Kitwanda, Divin Mazambi Mambo, Franklin Mweshi Kumbana, James Wakilongo Zangilwa, Cris Kacita, Esto Bahizire, Wyvine Ansima Bapolisi, Bertin C Bisimwa, Arsène Daniel Nyalundja, Mudarshiru Bbuye, Claudine Mukashyaka, Marina Saleeb, Yves Jacquemyn, Kumar-Singh Samir, Osama A.A. Mohamed, Rosine Ali, Michael Kombozi Basika, Esaie Luzolu Kindombe, Mays Kisala, Augustin Ibanda, Baudouin Matiba Baudouin, Gaël Mukendi, Patrick Mutombo, Tona Lutete, Mariano Lusakibanza, Yves N. Lula, Patricia Kabuni, Hippy Lonza, Sylvain Mulumba, Henri Mutomboh, Yves-Ninon Kumuamba, Jules Alonga, Claude Shosongo, Katherine Cone, Trust Faraja Mukika, Patrick Kazuba Bugale, Salomon Mashupe Shangula, Levi Bugwaja, Stephanie Ngai, Jules Jackson, Nicola Low, Patrick D M C Katoto, Placide Mbala‐Kingebeni, Laurens Liesenborghs · 发表于：The Lancet · 年份：2025 · DOI：10.1016/s0140-6736(25)02309-8 · 被引用次数：6 · 研究领域：Poxvirus research and outbreaks、Viral Infections and Outbreaks Research、Cervical Cancer and HPV Research

BACKGROUND: Monkeypox virus (MPXV) has been linked to vertical transmission, but systematic data are scarce. We aimed to describe the sociodemographic, clinical, and virological characteristics and assess the frequency and determinants of adverse outcomes in pregnant women with MPXV clade I infection. METHODS: In this prospective cohort study, we pooled data from three cohort studies (MBOTE-SK, PREGMPOX, and Uvira mpox) and one randomised controlled trial (PALM007) conducted in the South Kivu, Maniema, and Sankuru provinces of DR Congo between Dec 29, 2022, and June 20, 2025. Pregnant women and adolescent girls with a PCR-confirmed diagnosis of mpox were followed up throughout hospitalisation for mpox, delivery, and until discharge during the postpartum period. We extracted data on sociodemographic characteristics, MPXV exposure, clinical and obstetric presentation, and laboratory results. In a univariable analysis, we examined factors associated with the following adverse outcomes: spontaneous or missed abortion (<20 weeks of gestation), stillbirth (≥20 weeks of gestation), preterm birth (<37 weeks of gestation), live birth of a neonate with macroscopic mpox-like lesions, early (first 7 days) neonatal death, congenital anomaly, or maternal death (during pregnancy or discharge postpartum). FINDINGS: We collected data from 89 pregnant women in the first (25 [28%]), second (31 [35%]), and third (33 [37%]) trimesters across all four studies: MBOTE-SK (36 [40%]), PREGMPOX (24 [27...