Mutations in Retroviral Genes Associated with Drug Resistance

作者：John W. Mellors, Raymond F. Schinazi, Brendan A. Larder · 年份：1996 · 被引用次数：291 · 研究领域：HIV/AIDS drug development and treatment、HIV Research and Treatment、HIV/AIDS Research and Interventions

The emergence of drug-resistant variants of HIV continues to be of prime interest in the fields of HIV disease pathogenesis and antiretroviral chemotherapy. Drug resistance is the inevitable conse-quence of incomplete suppression of HIV replication. The rapid replication rate of HIV and its inherent genetic variation lead to the generation of a seemingly limitless number of viral variants that exhibit