Oncologic multivisceral resections involving the pancreas: Short-term outcomes and risk-analysis

作者：Artur Rebelo, Bodil Andersson, Samik Kumar Bandyopadhyay, Paulina Bereza‐Carlson, Frederik Berrevoet, Bergþór Björnsson, Stefan A.W. Bouwense, Florian Bösch, Markus W. Büchler, N. Chatzizacharias, Laurent Coubeau, Marie Crede, Cristine Pathirannehalage Don, Pieter Dries, Matthäus Felsenstein, Isabella Frigerio, Alessandro Giardino, Tim R. Glowka, Parsa Hadesi, Vera Hartman, Karin Johansen, Marie Klein, Johannes Klose, Karl Knipper, Carl-Stephan Leonhardt, Martin Loos, Thomas Malinka, Giovanni Marchegiani, C. Månsson, Riccardo Pellegrini, Giampaolo Perri, L. Poelsler, Geert Roeyen, Michael Rousek, Pablo Sancho, Stina Schild-Suhren, Thomas Schmidt, Leyre Serrablo, Alejandro Serrablo, Andrew M. Smith, Gregor A. Stavrou, Oliver Strobel, Alexandra Strobel, Ignazio Tarantino, Jozef Urdzik, Tim O. Vilz, Roberta Vella, Johanna Wennerblom, Patricia Wyzlic, Jörg Kleeff · 发表于：International Journal of Surgery · 年份：2025 · DOI：10.1097/js9.0000000000003731 · 被引用次数：6 · 研究领域：Pancreatic and Hepatic Oncology Research、Colorectal Cancer Surgical Treatments、Esophageal Cancer Research and Treatment

OBJECTIVE: To evaluate short-term outcomes and identify predictors of morbidity and mortality following multivisceral oncologic resections involving the pancreas. SUMMARY BACKGROUND DATA: Multivisceral resections including the pancreas are required for locally advanced abdominal malignancies but are associated with considerable perioperative risk. While smaller series suggest acceptable outcomes in selected patients, large-scale international data are lacking to guide surgical decision-making and risk stratification. METHODS: This was a retrospective cohort study of 1,283 patients from 31 international centers who underwent multivisceral oncologic resections involving the pancreas. Patient demographics, tumor characteristics, operative details, and 90-day postoperative outcomes were analyzed. RESULTS: The cohort had a mean age of 64.7 years, and 54.7% were male. Distal pancreatectomy was the most frequent procedure (60.5%), and R0 resection was achieved in 60.9% of cases. Ninety-day mortality was 6.9%, highest in patients with gastric adenocarcinoma (16.7%). Major complications (Clavien-Dindo grade III-V) occurred in 34.4% of patients. Higher ASA classification and open surgical approach were independently associated with increased morbidity and mortality. Prolonged operative time was associated with morbidity only. Female gender and treatment at high-volume centers were protective. In patients with pancreatic tumors, resection involving the colon (OR 1.78, p<0.001), stomach ...