Modification of a SARS-CoV-2 spike-RBD targeting nanobody for pH-dependent binding and its chromatographic engineering for purification of WT and variant S-RBDs with mild elution conditions

作者：Xindan Zhang, Zimin Chen, Sheng Lin, Fanli Yang, Liyan Guo, Jing Yang, Lingling Wang, Xin Yuan, Pengli Xu, Bin He, Yu Cao, Jian Li, Qi Zhao, Jiong Li, Li Yang, Wei Wang, Zhenling Wang, Jinliang Yang, H. J. Yang, Guobo Shen, Xiawei Wei, Guangwen Lu · 发表于：International Journal of Biological Macromolecules · 年份：2025 · DOI：10.1016/j.ijbiomac.2025.149749 · 被引用次数：1 · 研究领域：Monoclonal and Polyclonal Antibodies Research、vaccines and immunoinformatics approaches、SARS-CoV-2 and COVID-19 Research