Mechanosensitive snoRNA-like circular RNA sno-circCNOT1 drives endothelial dysfunction and atherosclerosis

作者：Liqi Bi, Yihao Zhu, Ziqi Chen, Yiying Yang, Yanlong Leng, Huijie Wang, Jiajie Pan, Xiaozhe Zhang, Zekai Zeng, Yunjun Liang, Guifu Wu, Wendong Fan · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.122995 · 研究领域：Circular RNAs in diseases、Kruppel-like factors research、Inflammasome and immune disorders

sno-circCNOT1 is a mechanosensitive snoRNA-like circRNA that promotes endothelial pyroptosis and atherogenesis via the LMNA/METTL14/NLRP3 axis. METTL14-N offers a protein-based therapeutic approach, positioning this regulatory pathway as a druggable target for atherosclerosis.