Temporal trends and regional disparities in prostate cancer mortality in the United States, 1999–2023: an analysis of the CDC WONDER database

作者：Zixiong Chai, Sixiang Yan, Haolin Li, Xingyuan Dong, Sheng Li, Yi‐Ming Fan, Zhiwu Dong, Zhiwei He, Jianbin Zhou, Pengkai Lei, Peng Gu · 发表于：BMC Public Health · 年份：2025 · DOI：10.1186/s12889-025-25694-6 · 被引用次数：3 · 研究领域：Prostate Cancer Diagnosis and Treatment、Global Cancer Incidence and Screening、Health Promotion and Cardiovascular Prevention

BACKGROUND: Prostate cancer continues to be a major cause of cancer-related deaths among men in the United States. Despite declining mortality rates in recent decades, variations across race, region, urban-rural status, and age remain insufficiently characterized. Therefore, updated evidence is essential to inform effective prevention and control strategies. METHODS: Prostate cancer deaths (ICD-10 code C61) among the U.S. men aged ≥ 45 years from 1999 to 2023 were analyzed using the CDC WONDER database. Age-adjusted mortality rate (AAMR) was calculated per 100,000 population and standardized to the 2000 U.S. standard population. Temporal trends were examined using joinpoint regression to estimate annual percent change (APC) and average APC. Subgroup analyses were conducted by region, race, urban-rural status, and age, with additional assessments at the state level. RESULTS: Over the 25-year study period, 749,932 prostate cancer-related deaths were reported. Mortality initially declined but began to rise after 2013, reaching a peak of 33,860 deaths in 2023, reflecting a 'decline followed by rebound' pattern. Importantly, the increase in absolute deaths primarily reflects the effects of population aging. The AAMR decreased significantly overall (AAPC, -2.20%; P < .05), although the pace of decline slowed after 2013. This is likely influenced by changes in Prostate-Specific Antigen screening practices. Regionally, the South consistently exhibited the highest mortality, while the...