The lactic dehydrogenase-to-albumin ratio predicts acute kidney injury in patients with intracerebral hemorrhage: a multicenter cohort study

作者：Taotao Dong, Yangchun Xiao, Xiang Yuan, Peng Wang, Chao You, Fang Fang, Yu Zhang · 发表于：Frontiers in Neurology · 年份：2025 · DOI：10.3389/fneur.2025.1606881 · 被引用次数：1 · 研究领域：Intracerebral and Subarachnoid Hemorrhage Research、Acute Kidney Injury Research、Dialysis and Renal Disease Management

Background Acute kidney injury (AKI) is a common and serious complication in patients with intracerebral hemorrhage (ICH), contributing to poor clinical outcomes. The lactic dehydrogenase-to-albumin ratio (LAR) has emerged as a promising biomarker combining markers of cellular injury and systemic inflammation. However, its role in predicting AKI in ICH patients remains unexplored. Objective This study aims to evaluate the predictive value of LAR for AKI in ICH patients and assess its potential to enhance predictive models for AKI risk. Methods We conducted a retrospective, multicenter cohort study involving 6,465 patients with spontaneous ICH from three hospitals in China. LAR was calculated from routine laboratory values (lactic dehydrogenase and albumin), and its association with AKI was analyzed using logistic regression and receiver operating characteristic (ROC) curves. Subgroup analyses were performed to explore heterogeneity in the relationship between LAR and AKI. Results Higher LAR values were significantly associated with increased risk of AKI. Patients with LAR >5.61 had a higher odds ratio (OR 2.51, 95% CI 2.13–2.96) for developing AKI compared to those with lower LAR. A dose-response relationship was observed, with progressively higher AKI risk across LAR quartiles. Incorporating LAR into existing predictive models improved the accuracy from 0.73 to 0.76 ( p < 0.001). Subgroup analysis revealed that age and hematoma volume influenced the strength of...