Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: etiology and sex-dependent differences

作者：Bence Hegyi, Logan R.J. Bailey, Juliana Mira Hernández, Christopher Y. Ko, Erin Y. Shen, Julie Bossuyt, Jennifer Davis, Donald M. Bers · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：2025 · DOI：10.1152/ajpheart.00227.2025 · 被引用次数：7 · 研究领域：Cardiac electrophysiology and arrhythmias、Cardiovascular Function and Risk Factors、Congenital heart defects research

signaling-contraction coupling (ECC) mechanisms are fundamental to heart function. ECC mechanisms are differentially altered in murine models of heart failure with preserved ejection fraction (HFpEF) by dominant disease pathology and sex. Diastolic dysfunction is more pronounced in diabetic-obese HFpEF mice (worse in females) than in hypertensive-obese HFpEF mice (female sex is protective). Diabetic-obese mice and primarily hypertensive-obese HFpEF mice exhibit differential ECC alterations and largely distinctive transcription changes, providing mechanistic insights into HFpEF sub-phenogroups.