GSNOR deletion differentially alters age-related cardiac function in a sex-dependent manner

作者：Obialunanma V. Ebenebe, Raihan Kabir, Allison Booher, Haley Garbus, Charles D. Cohen, Vivek Jani, Brian L. Lin, Luigi Adamo, Mark J. Kohr · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：2025 · DOI：10.1152/ajpheart.00681.2025 · 被引用次数：2 · 研究领域：Redox biology and oxidative stress、Nitric Oxide and Endothelin Effects、Cardiac Fibrosis and Remodeling

GSNOR deficiency appears beneficial to cardiac aging in both sexes, but at the cellular level, we discovered a sex disparity and the potential for underlying cellular dysfunction in female hearts. Taken together, GSNOR deficiency may present a mechanism through which the female heart specifically is at a higher risk of age-related cardiovascular disease and may represent a potential clinical target.