Multivariate Brain-Blood Signatures in Early-Stage Depression and Psychosis

作者：David Popovic, Clara Weyer, Dominic Dwyer, Siân Lowri Griffiths, Paris Alexandros Lalousis, Nicholas M. Barnes, Clara Vetter, L. Neuner, Madalina-Octavia Buciuman, Elif Sarisik, Marco Paolini, Theresa Lichtenstein, Lana Kambeitz‐Ilankovic, Joseph Kambeitz, Stephan Ruhrmann, Katharine Chisholm, Frauke Schultze‐Lutter, Peter Falkai, Kolja Schiltz, Johann Steiner, Michael J. Ziller, Giulio Pergola, Giuseppe Blasi, Alessandro Bertolino, Georg Romer, Rebekka Lencer, Udo Dannlowski, Raimo K. R. Salokangas, Christos Pantelis, Paolo Brambilla, Stefan Borgwardt, Stephen J. Wood, Eva Meisenzahl, Nikolaos Koutsouleris, Rachel Upthegrove, Shalaila S. Haas, Alkomiet Hasan, Claudius Hoff, Ifrah Khanyaree, Camilla Krämer, Aylin Melo, Susanna Muckenhuber-Sternbauer, Yanis Köhler, Ömer Öztürk, Nora Penzel, Adrian Rangnick, Sebastian von Saldern, Rachele Sanfelici, Moritz Spangemacher, Ana Tupac, María Fernanda Urquijo, Johanna Weiske, Antonia Wosgien, Karsten Blume, Dennis M. Hedderich, Dominika Julkowski, Nathalie Kaiser, Theresa Lichtenstein, Ruth Milz, Alexandra Nikolaides, Tanja Pilgram, Mauro Seves, Martina Wassen, Christina Andreou, Laura Egloff, Fabienne Harrisberger, Ulrike Heitz, Claudia Lenz, Letizia Leanza, Amatya Mackintosh, Renata Smieskova, Erich Studerus, Anna Walter, Sonja Widmayer, Chris Day, Mariam Iqbal, Mirabel Pelton, Pavan Mallikarjun, Alexandra Stainton, Ashleigh Lin, Alexander Denissoff, Anu Ellilä, Tiina From, Markus Heinimaa, Tuula Ilonen, Päivi Jalo, Heikki Laurikainen, Antti Luutonen, Akseli Mäkela, Janina Paju, Henri Pesonen, Reetta-Liina Säilä, Anna Toivonen, Otto Turtonen, Sonja Botterweck, Norman Kluthausen, Gerald Antoch, Julian Caspers, Hans‐Jörg Wittsack, Grazia Caforio, Leonardo Fazio, Tiziana Quarto, Barbara Gelao, Raffaella Romano, Ileana Andriola, Andrea Falsetti, Marina Barone, Roberta Passiatore, Marina Sangiuliano, Marian Surmann, Olga Bienek, Ana Beatriz Solana, Manuela Abraham, Timo Schirmer, Carlo Altamura, Marika Belleri, Francesca Bottinelli, Adele Ferro, Marta Re, Emiliano Monzani, Maurizio Sberna, Armando D’Agostino, Lorenzo Del Fabro, Giampaolo Perna, Maria Nobile, Alessandra Alciati, Matteo Balestrieri, Carolina Bonivento, Giuseppe Cabras, Franco Fabbro, Marco Garzitto, Sara Piccin · 发表于：JAMA Psychiatry · 年份：2025 · DOI：10.1001/jamapsychiatry.2025.3803 · 被引用次数：4 · 研究领域：Tryptophan and brain disorders、Stress Responses and Cortisol、Treatment of Major Depression

Importance: Inflammation is increasingly implicated in the pathophysiology of mood and psychotic disorders. Integrating blood biomarkers and brain imaging may help uncover mechanistic pathways and guide targeted interventions. Objective: To identify shared and distinct multivariate patterns of peripheral inflammation and gray matter volume (GMV) in early-stage depressive and psychotic disorders using a transdiagnostic machine learning approach. Design, Setting, and Participants: The naturalistic multicenter PRONIA study was conducted between February 2014 and May 2019 with a follow-up period of up to 36 months; baseline data were analyzed between August 2021 and April 2024. Eight sites, including inpatient and outpatient facilities, in 5 European countries (Germany, Italy, Switzerland, Finland, and the United Kingdom) were included. The study included individuals with recent-onset depression (ROD, n = 163) or psychosis (ROP, n = 177) or clinical high-risk states for psychosis (CHR-P, n = 172), all with minimal medication exposure, and healthy control (HC) individuals (n = 166). Exposures: Structural magnetic resonance imaging (MRI), peripheral assays of cytokines (eg, interleukin [IL] 6, IL-1β, tumor necrosis factor [TNF] α, C-reactive protein [CRP], brain-derived neurotrophic factor [BDNF], S100 calcium-binding protein B [S100B]); clinical assessments; neurocognitive testing. Main Outcomes and Measures: After data collection, sparse partial least squares was used to identify...