Gestational and lactational dietary supplementation with live yeast partially attenuates inflammatory responses to lipopolysaccharide challenge in newly weaned piglets

作者：Yuechi Fu, Abiola S Lawal, Timothy A. Johnson, Theresa Casey, Jun Xie, O. Adeola, Kolapo M. Ajuwon · 发表于：Journal of Animal Science · 年份：2025 · DOI：10.1093/jas/skaf435 · 被引用次数：1 · 研究领域：Animal Behavior and Welfare Studies、Animal Nutrition and Physiology、Gut microbiota and health

Weaning is an abrupt event in the life of piglets that adversely affects metabolic homeostasis, leading to poor nutrient absorption, increased susceptibility to enteric pathogens, and reduced growth performance. Few studies have examined the effects of maternal dietary live yeast (LY) supplementation on the responses of piglets subjected to an immunological challenge immediately after weaning. The aim of this study was to evaluate the effects of gestational and lactational dietary LY supplementation on inflammatory and antioxidant markers in newly weaned piglets challenged with lipopolysaccharide (LPS). On day 77 of gestation, 40 sows were randomly assigned to two dietary treatments: without (CON) or with LY supplementation at 0.05% of the diet during gestation and 0.1% during lactation. Within 24 h postweaning, 16 piglets with similar weights were selected from each maternal group and intraperitoneally injected with sterile saline or LPS, resulting in four treatment groups (n = 8): 1) CON + saline (CS), 2) LY + saline (YS), 3) CON+ LPS (CLPS), and 4) LY + LPS (YLPS). Rectal temperature was measured hourly for 4 h post-injection, after which piglets were euthanized. Samples of the mesenteric lymph node, liver, muscle, and intestinal mucosa were collected at 4 h post-injection to detect maternal LY-induced physiological changes in piglets. Results showed that YLPS piglets tended to have a lower rectal temperature than CLPS piglets at 3 h post-injection (P = 0.09). Levels of tu...