Association between intrinsic capacity, changes in intrinsic capacity, and cardiometabolic multimorbidity: results from three prospective cohort studies

作者：Ziyue Wang, Lu Wang, Lulu Tang, Xiaorui Li, Yu Tao Lu, Xiaoli Yu, Fei Liu, Xiaoping Zhu · 发表于：Frontiers in Endocrinology · 年份：2025 · DOI：10.3389/fendo.2025.1738997 · 被引用次数：2 · 研究领域：Chronic Disease Management Strategies、Heart Failure Treatment and Management、Cardiovascular Function and Risk Factors

Background Intrinsic capacity (IC)is closely associated with cardiometabolic health in middle-aged and older adults. The purpose of this study was to determine the associations of baseline IC, cumulative IC scores, and their dynamic changes with the risk of incident cardiometabolic multimorbidity (CMM). Methods Using data from three prospective cohorts, the China Health and Retirement Longitudinal Study (CHARLS), the English Longitudinal Study of Ageing (ELSA), and the Health and Retirement Study (HRS), participants who met the eligibility criteria were included in this study. Kaplan-Meier curves and Cox models analyzed risk trends and associations. Results A total of 11,916 participants were included based on the inclusion and exclusion criteria. At baseline, the risk of CMM in the injured group was significantly higher than that in the non-injured group(Pooled: HR = 1.40, 95% CI 1.30-1.52, P < 0.001); Cumulative IC scores showed a graded association with CMM risk: individuals with moderately reduced scores (≈1 SD below intact) had higher risk (HR = 1.22, 95% CI 1.09–1.36), and those with substantially reduced scores (>1 SD below intact) had even higher risk (HR = 1.61, 95% CI 1.47–1.78). For dynamic changes, CMM risk was significantly higher in persistent impairment and decline groups; even the improvement group had higher risk than the no-decline group (Decline: HR = 1.25, 95% CI 1.10-1.42, P < 0.001; Improvement: HR = 1.28, 95% CI 1.13-1.45, P &lt...