Off‐label dosing of long‐acting injectable cabotegravir and rilpivirine during pregnancy: A case study with therapeutic drug monitoring

作者：Natella Rakhmanina, Justin Unternaher, Tierra Williams, Kevin J. Ryan, Kedria Walker, Edward P. Acosta, John van den Anker, Rachel K. Scott · 发表于：British Journal of Clinical Pharmacology · 年份：2025 · DOI：10.1002/bcp.70424 · 被引用次数：3 · 研究领域：Pregnancy and Medication Impact、Pharmacovigilance and Adverse Drug Reactions、HIV-related health complications and treatments

Abstract We report individualized off‐label monthly use of a high dose of long‐acting intramuscular cabotegravir/rilpivirine (CAB/RPV = 600 mg/900 mg) co‐administered preconceptionally and throughout pregnancy with subcutaneous lenacapavir to a young woman with perinatally acquired HIV, multiple comorbidities, and class III obesity. Therapeutic drug monitoring for CAB and RPV was performed throughout the pregnancy and postpartum. At 7 weeks gestation, the plasma CAB and RPV C troughs were 16 (2.58 mg/L) and 9 (0.11 mg/L) times above the respective protein adjusted (PA)‐IC 90 . From 7 to 32 weeks of gestation, plasma CAB and RPV C troughs decreased to 1.28 and to 0.08 mg/L, respectively, but remained above PA‐IC 90 for both drugs. After receiving one monthly high‐dose CAB/RPV injection after delivery at 7 weeks postpartum, the plasma CAB and RPV C troughs were 4.02 and 0.19 mg/L, 56% and 73% higher than at 7 weeks of gestation. Despite a decrease in cabotegravir (50%) and rilpivirine (27%) concentrations between first and third trimesters, plasma exposures remained above therapeutic thresholds and viral load <20 copies/mL was maintained throughout pregnancy. Higher CAB and RPV exposures did not result in adverse maternal, pregnancy or infant safety outcomes. At 7 weeks postpartum, CAB/RPV was switched to standard bimonthly dosing. At 33 weeks postpartum, the patient remained undetectable on standard CAB/RPV bimonthly dose, although subsequent pregnancies might require long‐...