The influence of kidney function on the prognostic value of cardiac troponin

作者：Rasmus Bo Hasselbalch, Martin Schultz, Nicholas Carlson, Nina Strandkjær, Sophie Sander Knudsen, Alexander Holst Kronborg, Kristian Kragholm, Mikkel Porsborg Andersen, Henning Bundgaard, Christian Torp‐Pedersen, Kristin M. Aakre, Kasper Iversen · 发表于：Clinical Biochemistry · 年份：2025 · DOI：10.1016/j.clinbiochem.2025.111068 · 被引用次数：2 · 研究领域：Acute Myocardial Infarction Research、Cardiac Imaging and Diagnostics、Venous Thromboembolism Diagnosis and Management

BACKGROUND: Kidney function influences the concentration of cardiac troponin T (cTnT) and I (cTnI). We investigate how this impacts their prognostic ability. METHODS: This Danish nationwide study included patients from 2013 to 2023 with at least two measurements of Roche hs-cTnT, Abbott hs-cTnI, or Siemens hs-cTnI Vista or Atellica during the index admission. Patients were stratified by estimated glomerular filtration rate (eGFR). We assessed prognostic ability by Cox models and area under the receiver operating characteristics curve (AUC). The primary endpoint was 30-day all-cause mortality. RESULTS: the optimal cutoff was 16.5 ng/l for hs-cTnT and below the sex-specific 99th percentile for all hs-cTnI assays, increasing 5-20-fold with lower eGFR for all assays. CONCLUSION: Kidney function affects cTn prognostic performance, with reduced predictive ability and higher optimal cutoff concentrations for lower eGFR.