LLDT-8 attenuates brain metastasis in non-small cell lung cancer via selective p53 activation

作者：Junjie Liu, Lun Liang, Zhenning Wang, Kaiwei Wei, Zhi-Jie Liang, Junlei Chang, Rongfeng Lan, Chunhua Wang, Min Yu · 发表于：RSC Medicinal Chemistry · 年份：2025 · DOI：10.1039/d5md00754b · 被引用次数：1 · 研究领域：Natural Compounds in Disease Treatment、Flavonoids in Medical Research、Glioma Diagnosis and Treatment

, LLDT-8 significantly suppressed BM growth, achieving superior intracranial tumor control compared to triptolide, while eliciting no detectable systemic toxicity. These results identify LLDT-8 as a metastasis-selective agent that merges enhanced brain bioavailability with precise p53 pathway activation, providing a promising therapeutic strategy for NSCLC-derived BM.